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公开(公告)号：US06531472B2
公开(公告)日：2003-03-11
申请号：US10006173
申请日：2001-12-04
IPC分类号： A61K3140
CPC分类号： C07D295/116 , C07C259/06 , C07C2601/02 , C07C2602/10 , C07D213/50 , Y02P20/55
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, X and Y have the meanings defined in the specification. The compounds have histone deacetylase (HDAC) inhibitory activity which is useful in cancer treatment. Also provided is a process for making a compound of formula I by reacting a compound of formula III with a compound of formula IV wherein A is a displaceable group and PG is a protecting group.
摘要翻译： 本发明提供式I化合物和药学上可接受的盐，其中R1，R2，R3，R4，R5，X和Y具有本说明书中定义的含义。 该化合物具有可用于癌症治疗的组蛋白脱乙酰酶（HDAC）抑制活性。 还提供了通过使式III化合物与式IV化合物反应制备式I化合物的方法，其中A是可置换基团，PG是保护基团。
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2.发明授权Tricyclic lactam and sultam derivatives and their use as histone deacetylase inhibitors 失效三环内酰胺和苏丹衍生物及其作为组蛋白脱乙酰酶抑制剂的用途公开(公告)号：US07091229B2
公开(公告)日：2006-08-15
申请号：US10470121
申请日：2002-01-24
IPC分类号： A61K31/425 , A61K31/403 , C07D275/06 , C07D209/56
CPC分类号： C07D275/06 , C07D209/92
摘要： A compound of formula (I) wherein A and B are optionally substituted cyclohexenyl or phenyl groups, X is carbonyl or sulfonyl, and Y is 5–7 atoms-linker, is useful as histone deacetylase inhibitors, particularly for inhibiting cell proliferation.
摘要翻译： 式（I）的化合物，其中A和B为任选取代的环己烯基或苯基，X为羰基或磺酰基，Y为5-7个原子的连接体，可用作组蛋白脱乙酰酶抑制剂，尤其用于抑制细胞增殖。
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3.发明授权公开(公告)号：US06800638B2
公开(公告)日：2004-10-05
申请号：US10451757
申请日：2003-06-23
IPC分类号： C07D21704
CPC分类号： C07D471/04 , C07D217/04
摘要： A compound of the formula (I) wherein A, R1, R2 and X have the meanings defined in the specification, process of manufacturing such as compound and a pharmaceutical composition with HDAC inhibitor activity and anti-cell proliferation activity containing such a compound.
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公开(公告)号：US08703130B2
公开(公告)日：2014-04-22
申请号：US13570333
申请日：2012-08-09
申请人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人VEGF和针对人ANG-2的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20100041684A1
公开(公告)日：2010-02-18
申请号：US12444592
申请日：2007-12-19
申请人： Guy Georges , Matthias Koerner , Irene Kolm , Ulrike Reiff , Wolfgang Schaefer , Edgar Voss , Stefan Weigand
发明人： Guy Georges , Matthias Koerner , Irene Kolm , Ulrike Reiff , Wolfgang Schaefer , Edgar Voss , Stefan Weigand
IPC分类号： A61K31/505 , C07D239/47 , C07D239/56
CPC分类号： C07D239/47 , C07D405/12
摘要： Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式（I）的化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在 控制或预防癌症等疾病。
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公开(公告)号：US20120321627A1
公开(公告)日：2012-12-20
申请号：US13570333
申请日：2012-08-09
申请人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
IPC分类号： A61K39/395 , A61P9/00 , A61P35/00
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人VEGF和针对人ANG-2的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US08080552B2
公开(公告)日：2011-12-20
申请号：US12444592
申请日：2007-12-19
申请人： Guy Georges , Matthias Koerner , Irene Kolm , Ulrike Reiff , Wolfgang Schaefer , Edgar Voss , Stefan Weigand
发明人： Guy Georges , Matthias Koerner , Irene Kolm , Ulrike Reiff , Wolfgang Schaefer , Edgar Voss , Stefan Weigand
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04 , A61K31/505 , C07D239/02 , C07D239/00
CPC分类号： C07D239/47 , C07D405/12
摘要： Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式（I）的化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在 控制或预防癌症等疾病。
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公开(公告)号：US20100111967A1
公开(公告)日：2010-05-06
申请号：US12572289
申请日：2009-10-02
申请人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
IPC分类号： C07K16/22 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人VEGF和针对人ANG-2的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US08268314B2
公开(公告)日：2012-09-18
申请号：US12572289
申请日：2009-10-02
申请人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人VEGF和针对人ANG-2的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20130078251A1
公开(公告)日：2013-03-28
申请号：US13590904
申请日：2012-08-21
申请人： Olivier Freytag , Guy Georges , Ekkehard Moessner , Olaf Mundigl , Gérald Tuffin , Pablo Umana
发明人： Olivier Freytag , Guy Georges , Ekkehard Moessner , Olaf Mundigl , Gérald Tuffin , Pablo Umana
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/3053 , C07K2317/24 , C07K2317/33 , C07K2317/41 , C07K2317/732 , C07K2317/92
摘要： The invention provides anti-MCSP antibodies and methods of using the same.
摘要翻译： 本发明提供抗MCSP抗体及其使用方法。
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