发明授权
US06538127B1 Synthetic HIV-2 envelope genes containing modifications that lead to optimized expression in bacteria
失效
含有导致细菌表达最佳化的修饰的合成的HIV-2包膜基因
- 专利标题： Synthetic HIV-2 envelope genes containing modifications that lead to optimized expression in bacteria
- 专利标题（中）： 含有导致细菌表达最佳化的修饰的合成的HIV-2包膜基因
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申请号： US08443530申请日： 1995-05-18
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公开(公告)号： US06538127B1公开(公告)日： 2003-03-25
- 发明人: Sushil G. Devare , James M. Casey , Suresh M. Desai
- 申请人： Sushil G. Devare , James M. Casey , Suresh M. Desai
- 主分类号： C07H2104
- IPC分类号： C07H2104
摘要：
The present invention provides a method of synthesizing genes encoding unique HIV-1 and HIV-2 envelope proteins and their fragments, thereby allowing overexpression of these proteins in E. coli. The HIV envelope proteins and their fragments have been expressed at high levels as individual proteins or in fusion with other proteins. The HIV envelope proteins thus expressed in E. coli can be effectively used for the detection of exposure to HIV as well as the discrimination of HIV-1 and HIV-2.
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