Invention Grant
- Patent Title: Bioluminescent biosensor device
- Patent Title (中): 生物发光生物传感器装置
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Application No.: US09910360Application Date: 2001-07-20
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Publication No.: US06544729B2Publication Date: 2003-04-08
- Inventor: Gary S. Sayler , Steven A. Ripp , Bruce Applegate
- Applicant: Gary S. Sayler , Steven A. Ripp , Bruce Applegate
- Main IPC: C12O100
- IPC: C12O100

Abstract:
Disclosed are methods and devices for detection of bacteria based on recognition and infection of one or more selected strains of bacteria with bacteriophage genetically modified to cause production of an inducer molecule in the bacterium following phage infection. The inducer molecule is released from the infected bacterium and is detected by genetically modified bacterial bioreporter cells designed to emit bioluminescence upon stimulation by the inducer. Autoamplification of the bioluminescent signal permits detection of low levels of bacteria without sample enrichment. Also disclosed are methods of detection for select bacteria, and kits for detection of select bacteria based on the described technology.
Public/Granted literature
- US20030027241A1 BIOLUMINESCENT BIOSENSOR DEVICE Public/Granted day:2003-02-06
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