A method of generating a single-sideband optical frequency comb uses an optical fiber loop that contains an optical modulator and an optical amplifier. The optical modulator is used to generate a sideband signal on only one side of a reference signal. The signal thus generated is circulated in the fiber loop while using the amplifier to compensate for optical loss in the course of the circulation. In this way, at the output, a grid of frequency axis components is generated over a wide frequency span