发明授权
- 专利标题： Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections
- 专利标题（中）： 含有作为治疗活性剂脂肪酸或脂肪醇或其单甘油酯衍生物的局部制剂用于治疗粘膜感染
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申请号： US09297921申请日： 1999-12-16
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公开(公告)号： US06596763B1公开(公告)日： 2003-07-22
- 发明人: Halldor Thormar , Thordis Kristmundsdottir
- 申请人： Halldor Thormar , Thordis Kristmundsdottir
- 优先权： IS4386 19961114
- 主分类号： A61K3121
- IPC分类号： A61K3121
摘要：
The present invention relates to a method for counteracting infections caused by bacteria, fungi or virus such as Herpes Simplex Virus in skin or mucosal membranes, in particular genital membranes, of a mammal. The method comprises topically administering to the skin or mucosal membrane an effective amount of a formulation comprising a) at least one microbicidal lipid, b) at least one solubilizing agent which keeps the lipid dissolved in the formulation, and optionally 3) a gel-forming agent. The formulation used in the method may suitable be in the form of a hydrogel. The microbicidal lipid is preferably a C6-18 fatty acid, such as, e.g., lauric acid, or a derivative thereof, e.g., a monoglyceride such as capric acid 1-monoglyceride. The solubilizing agent may suitably be a glycofurol such as the commercially-available glycofurol 75. The invention also relates to novel pharmaceutical formulations for use in the method.
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