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    Methods and formulations for counteracting infection of mucosa or skin
    2.
    发明申请
    Methods and formulations for counteracting infection of mucosa or skin 审中-公开
    抵抗粘膜或皮肤感染的方法和配方

    公开(公告)号：US20050043402A1

    公开(公告)日：2005-02-24

    申请号：US10408235

    申请日：2003-04-08

    申请人： Halldor Thormar ,  Thordis Kristmundsdottir

    发明人： Halldor Thormar ,  Thordis Kristmundsdottir

    IPC分类号： A61K9/00 ,  A61K31/045 ,  A61K31/08 ,  A61K31/20 ,  A61K31/201 ,  A61K31/23 ,  A61K31/231 ,  A61K31/225

    CPC分类号： A61K31/231 ,  A61K9/0034 ,  A61K31/045 ,  A61K31/08 ,  A61K31/20 ,  A61K31/201 ,  A61K31/23

    摘要： The present invention relates to a method for preventing infection of the genital mucosa of a mammal by virus, pathogenic bacteria or fungi, comprising topically administering, to the genital mucosa of the mammal, an effective prophylactic amount of a formulation comprising a hydrogel which comprises a microbicidal lipid as an active ingredient, a water gelling agent and a solubilizing agent. The microbicidal lipid is preferably a C6-18 fatty acid or salt thereof, fatty acid monoglycerides, fatty acid esters of monohydric alcohols, fatty alcohols or fatty alcohol monoglycerides ether.

    摘要翻译： 本发明涉及通过病毒，致病菌或真菌预防哺乳动物的生殖器粘膜的感染的方法，该方法包括向哺乳动物的生殖器粘膜局部施用有效的预防量的包含水凝胶的制剂，其包含 杀微生物脂质作为活性成分，水凝胶剂和增溶剂。 杀微生物脂质优选为C6-18脂肪酸或其盐，脂肪酸单甘油酯，一元醇的脂肪酸酯，脂肪醇或脂肪醇单甘油酯醚。

    Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections
    4.
    发明授权
    Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections 失效
    含有作为治疗活性剂脂肪酸或脂肪醇或其单甘油酯衍生物的局部制剂用于治疗粘膜感染

    公开(公告)号：US06596763B1

    公开(公告)日：2003-07-22

    申请号：US09297921

    申请日：1999-12-16

    申请人： Halldor Thormar ,  Thordis Kristmundsdottir

    发明人： Halldor Thormar ,  Thordis Kristmundsdottir

    IPC分类号： A61K3121

    CPC分类号： A61K31/231 ,  A61K9/0034 ,  A61K31/045 ,  A61K31/08 ,  A61K31/20 ,  A61K31/201 ,  A61K31/23

    摘要： The present invention relates to a method for counteracting infections caused by bacteria, fungi or virus such as Herpes Simplex Virus in skin or mucosal membranes, in particular genital membranes, of a mammal. The method comprises topically administering to the skin or mucosal membrane an effective amount of a formulation comprising a) at least one microbicidal lipid, b) at least one solubilizing agent which keeps the lipid dissolved in the formulation, and optionally 3) a gel-forming agent. The formulation used in the method may suitable be in the form of a hydrogel. The microbicidal lipid is preferably a C6-18 fatty acid, such as, e.g., lauric acid, or a derivative thereof, e.g., a monoglyceride such as capric acid 1-monoglyceride. The solubilizing agent may suitably be a glycofurol such as the commercially-available glycofurol 75. The invention also relates to novel pharmaceutical formulations for use in the method.

    摘要翻译： 本发明涉及一种用于抵抗由细菌，真菌或病毒如单纯疱疹病毒在皮肤或粘膜（特别是生殖器膜）中引起的感染的方法。 该方法包括向皮肤或粘膜施用有效量的制剂，其包含a）至少一种杀微生物脂质，b）至少一种使脂质溶解在制剂中的增溶剂，以及任选地3）凝胶形成 代理商 该方法中使用的制剂可以是水凝胶的形式。 杀微生物脂质优选为C6-18脂肪酸，例如月桂酸或其衍生物，例如单酸甘油酯，例如癸酸1-单甘油酯。 增溶剂可以合适地是糖福豆醇，例如可商购的糖醇75.本发明还涉及用于该方法的新型药物制剂。