发明授权
US06603017B2 Preparation of 2-alkyl-3-(4,5-dihydroisoxazol-3-yl) halobenzenes
有权
2-烷基-3-(4,5-二氢异恶唑-3-基)卤代苯的制备
- 专利标题: Preparation of 2-alkyl-3-(4,5-dihydroisoxazol-3-yl) halobenzenes
- 专利标题(中): 2-烷基-3-(4,5-二氢异恶唑-3-基)卤代苯的制备
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申请号: US10141236申请日: 2002-05-09
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公开(公告)号: US06603017B2公开(公告)日: 2003-08-05
- 发明人: Michael Rack , Norbert Götz , Helmut Hagen , Wolfgang von Deyn , Ernst Baumann , Rene Lochtman , Joachim Gebhardt
- 申请人: Michael Rack , Norbert Götz , Helmut Hagen , Wolfgang von Deyn , Ernst Baumann , Rene Lochtman , Joachim Gebhardt
- 优先权: DE19853039 19981118
- 主分类号: C07D26118
- IPC分类号: C07D26118
摘要:
A novel process for preparing the compounds of the formula I where: n is 0, 1 or 2; R1, R2 are C1-C6-alkyl; R3, R4, R5 are hydrogen or C1-C6-alkyl, or R4 and R5 together form a bond; R6 is Cl, Br, which comprises a synthesis sequence starting from 1,2-dialkylbenzenes of the formula II with subsequent halogenation to give 3,6-dihalo-1,2-dialkylbenzenes, haloalkylation to give benzyl bromides, oxidation to give benzaldehydes, oximation, reaction with alkenes to give isoxazoles, conversion into thioethers and, if appropriate, oxidation to give sulfenyl or sulfonyl derivatives of the formula I.
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