- 专利标题: Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
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申请号: US09844265申请日: 2001-04-27
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公开(公告)号: US06610489B2公开(公告)日: 2003-08-26
- 发明人: Alan Wolffe , Fyodor Urnov , Dmitry Guschin , Trevor Collingwood , Xiao-Yong Li , Brian Johnstone
- 申请人: Alan Wolffe , Fyodor Urnov , Dmitry Guschin , Trevor Collingwood , Xiao-Yong Li , Brian Johnstone
- 主分类号: C12Q168
- IPC分类号: C12Q168
摘要:
Methods for the identification of a drug target, wherein the drug target is a component of a signal transduction pathway, are provided. The methods are based, in part, on selection of a gene of therapeutic interest and determination of regulatory DNA sequences which regulate expression of the gene in a cell of interest, followed by reconstruction of signal transduction pathways which act on molecules which bind to the regulatory sequence. Also provided are methods for assessing potential pharmacological effects and/or side effects of an agent, based on the effect of the agent on the distribution and properties of accessible regions in cellular chromatin.