发明授权
- 专利标题： Aspartic protease inhibitors
- 专利标题（中）： 天冬氨酸蛋白酶抑制剂
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申请号： US09868775申请日： 2001-09-28
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公开(公告)号： US06613764B1公开(公告)日： 2003-09-02
- 发明人: Ramnarayan S. Randad , John W. Erickson , Michael A. Eissenstat , Lucyna Lubkowska
- 申请人： Ramnarayan S. Randad , John W. Erickson , Michael A. Eissenstat , Lucyna Lubkowska
- 主分类号： A61K315377
- IPC分类号： A61K315377
摘要：
The present invention provides a compound of formula (I) wherein a, b, c, d, and e, are R7, OR7, SR7, NR7R8, NHCOR7, CO2R7, CN, NO2, NH2, N3, or a halogen. R7 and R8 are H or alkyl, R1 and R2 are H or alkyl, and R3 is a non-aromatic substituent. Substituent A is OH, NH2, or SH. Substituents B and B1 include amide and sulfonamide groups, which can be cyclic, acyclic, or amino acid derivatives. Alternatively, B and R′ together with the nitrogen to which they are bonded, and/or B′ and R2 together with the nitrogen to which they are bonded, define a heterocycle. The present invention further provides a pharmaceutical composition that includes a carrier and a therapeutically effective amount of at least one compound of the present invention. The present invention further provides therapeutic methods that include administering a therapeutically effective amount of at least one compound of the present invention
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