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91 条记录 (耗时 0.033 秒)

    Aspartic protease inhibitors
    2.
    发明授权
    Aspartic protease inhibitors 有权
    天冬氨酸蛋白酶抑制剂

    公开(公告)号：US06613764B1

    公开(公告)日：2003-09-02

    申请号：US09868775

    申请日：2001-09-28

    申请人： Ramnarayan S. Randad ,  John W. Erickson ,  Michael A. Eissenstat ,  Lucyna Lubkowska

    发明人： Ramnarayan S. Randad ,  John W. Erickson ,  Michael A. Eissenstat ,  Lucyna Lubkowska

    IPC分类号： A61K315377

    CPC分类号： C07D207/27 ,  C07C235/20 ,  C07C235/50 ,  C07C237/34 ,  C07C271/20 ,  C07C271/22 ,  C07C311/29 ,  C07D211/60 ,  C07D213/30 ,  C07D215/48 ,  C07D239/10 ,  C07D277/24 ,  C07D295/215 ,  C07D307/20 ,  C07D405/12 ,  C07D417/12

    摘要： The present invention provides a compound of formula (I) wherein a, b, c, d, and e, are R7, OR7, SR7, NR7R8, NHCOR7, CO2R7, CN, NO2, NH2, N3, or a halogen. R7 and R8 are H or alkyl, R1 and R2 are H or alkyl, and R3 is a non-aromatic substituent. Substituent A is OH, NH2, or SH. Substituents B and B1 include amide and sulfonamide groups, which can be cyclic, acyclic, or amino acid derivatives. Alternatively, B and R′ together with the nitrogen to which they are bonded, and/or B′ and R2 together with the nitrogen to which they are bonded, define a heterocycle. The present invention further provides a pharmaceutical composition that includes a carrier and a therapeutically effective amount of at least one compound of the present invention. The present invention further provides therapeutic methods that include administering a therapeutically effective amount of at least one compound of the present invention

    摘要翻译： 本发明提供式（I）化合物，其中a，b，c，d和e分别是R 7，OR 7，SR 7，NR 7 R 8，NHCOR 7，CO 2 R 7，CN，NO 2，NH 2，N 3或卤素。 R 7和R 8是H或烷基，R 1和R 2是H或烷基，R 3是非芳族取代基。 取代基A是OH，NH 2或SH。 取代基B和B1包括酰胺和磺酰胺基团，其可以是环状，非环状或氨基酸衍生物。 或者，B和R'与它们所键合的氮一起，和/或B'和R 2与它们所键合的氮一起定义杂环。 本发明还提供了包含载体和治疗有效量的至少一种本发明化合物的药物组合物。 本发明进一步提供治疗方法，其包括施用治疗有效量的至少一种本发明化合物

    Antiviral agents for the treatment, control and prevention of infections by coronaviruses
    9.
    发明授权
    Antiviral agents for the treatment, control and prevention of infections by coronaviruses 有权
    用于治疗，控制和预防冠状病毒感染的抗病毒剂

    公开(公告)号：US07151163B2

    公开(公告)日：2006-12-19

    申请号：US10833304

    申请日：2004-04-28

    申请人： John W. Erickson ,  Abelardo Silva

    发明人： John W. Erickson ,  Abelardo Silva

    IPC分类号： C07K14/165 ,  C07K17/00 ,  A61K39/215 ,  A61K39/385

    CPC分类号： C07K14/005 ,  A61K38/162 ,  C12N2770/20022

    摘要： The invention provides compositions and methods that are useful for preventing and treating a coronavirus infection in a subject. More specifically, the invention provides peptides and conjugates and pharmaceutical compositions containing those peptides and conjugates that block fusion of a coronavirus, such as the SARS virus, to a target cell. This blocking mechanism prevents or treats a coronavirus infection, such as a SARS infection, in a subject, such as a human subject.

    摘要翻译： 本发明提供可用于预防和治疗受试者冠状病毒感染的组合物和方法。 更具体地，本发明提供了含有阻断冠状病毒例如SARS病毒融合的那些肽和缀合物的肽和缀合物和药物组合物与靶细胞。 这种阻断机制防止或治疗诸如人受试者的受试者中的冠状病毒感染，例如SARS感染。

    Lube oil ring pump
    10.
    发明授权
    Lube oil ring pump 失效
    润滑油环泵

    公开(公告)号：US4591024A

    公开(公告)日：1986-05-27

    申请号：US591210

    申请日：1984-03-19

    申请人： John W. Erickson

    发明人： John W. Erickson

    IPC分类号： F04B19/10 ,  F16N7/22 ,  F01M9/06

    CPC分类号： F16N7/22

    摘要： A lubrication system for moveable machine parts within a housing have a sump containing a fluid and a rotatable shaft comprising a ring eccentrically encircling and being frictionally rotated by shaft, ring being at least partially immersed in sump fluid to carry fluid during rotation for machine parts, a plurality of fluid carrying fins attached to ring to increase the fluid carrying capacity of ring, fins commencing from each outer edge and extending partially inwardly along the ring width towards each other thereby forming an annular space between fins and ring, conduit means having an inlet located within annular space for receiving fluid carried in annular space and delivering fluid to moveable machine parts, and first and second abutments attach to shaft, one on each side of ring and spaced from ring sufficiently to form an axial gap for a fluid film which transmits rotational power from abutments to ring.

    摘要翻译： 用于壳体内的可移动机器部件的润滑系统具有容纳流体的贮槽和可旋转轴，其包括偏心环绕的环，并且通过轴摩擦地旋转，环至少部分地浸没在贮槽流体中以在机器部件的旋转期间承载流体， 附接到环上的多个流体承载翅片以增加环的流体承载能力，从每个外边缘开始并沿着环宽度朝向彼此部分地向内延伸，从而在翅片和环之间形成环形空间，导管装置具有入口 位于环形空间内，用于接收携带在环形空间中的流体并且将流体输送到可移动的机器部件，并且第一和第二邻接件附接到轴，一个在环的每一侧上并与环隔开，以形成用于流体膜的轴向间隙， 从基座到环的旋转动力。