发明授权
US06645982B2 Crystal forms of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethynyl-phenyl)-1-methyl-1H-quinolin-2-one, 2,3-dihydroxybutanedioate salts and method of production
失效
6 - [（4-氯 - 苯基） - 羟基 - （3-甲基-3H-咪唑-4-基） - 甲基] -4-（3-乙炔基 - 苯基）-1-甲基-1H-喹啉的晶型 2,3-二羟基丁二酸盐及其制备方法
![Crystal forms of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethynyl-phenyl)-1-methyl-1H-quinolin-2-one, 2,3-dihydroxybutanedioate salts and method of production](/docs/US/2003-11-11/US06645982B2/abs.jpg.600x600.jpg)
- 专利标题： Crystal forms of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethynyl-phenyl)-1-methyl-1H-quinolin-2-one, 2,3-dihydroxybutanedioate salts and method of production
- 专利标题（中）： 6 - [（4-氯 - 苯基） - 羟基 - （3-甲基-3H-咪唑-4-基） - 甲基] -4-（3-乙炔基 - 苯基）-1-甲基-1H-喹啉的晶型 2,3-二羟基丁二酸盐及其制备方法
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申请号： US10021201申请日： 2001-12-07
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公开(公告)号： US06645982B2公开(公告)日： 2003-11-11
- 发明人: Joseph P. Lyssikatos , Derek L. Tickner , Linda S. Newton , Zheng J. Li , Clifford N. Meltz
- 申请人： Joseph P. Lyssikatos , Derek L. Tickner , Linda S. Newton , Zheng J. Li , Clifford N. Meltz
- 主分类号： A61K3147
- IPC分类号： A61K3147
![Crystal forms of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethynyl-phenyl)-1-methyl-1H-quinolin-2-one, 2,3-dihydroxybutanedioate salts and method of production](/abs-image/US/2003/11/11/US06645982B2/abs.jpg.150x150.jpg)
摘要：
The invention relates to crystal forms of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethynyl-phenyl)-1-methyl-1H-quinolin-2-one, 2,3-dihydroxy butanedioate salts having the formula shown below: and to pharmaceutical compositions containing the above compound, methods of treating hyperproliferative diseases, such as cancers, in mammals, especially humans by administering the above compound, and to methods of preparing the crystal forms of the above compound and related compounds.
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