发明授权
- 专利标题: 1,4-dihydropyridine compounds as bradykinin antagonists
- 专利标题(中): 1,4-二氢吡啶化合物作为缓激肽拮抗剂
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申请号: US09903157申请日: 2001-07-11
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公开(公告)号: US06653313B2公开(公告)日: 2003-11-25
- 发明人: Mitsuhiro Kawamura , Makoto Kawai , Yuji Shishido , Tomoki Kato , Yasuhiro Katsu , Takafumi Ikeda , Noriaki Murase
- 申请人: Mitsuhiro Kawamura , Makoto Kawai , Yuji Shishido , Tomoki Kato , Yasuhiro Katsu , Takafumi Ikeda , Noriaki Murase
- 主分类号: A61K31496
- IPC分类号: A61K31496
摘要:
The present invention relates to compounds of the formula wherein each A is independently halo; Y is —(CH2)m—, —C(O)— or —S(O)—; R1 and R2 are independently C1-4 alkyl; R3 is substituted azacycloalkyl etc.; R4 is phenyl substituted at the 2-position with a substituent selected from substituted C1-7 alkyl, substituted C1-7 alkoxy, amine, etc; R5 is hydrogen or C1-4 alkyl; m is 0, 1 or 2; and n is 0, 1, 2, 3, 4 or 5. The present invention also relates to pharmaceutical compositions containing such compounds and to the use of such compounds in the treatment and prevention of inflammation, asthma, allergic rhinitis, pain and other disorders.
公开/授权文献
- US20020161006A1 1,4-dihydropyridine compounds as bradykinin antagonists 公开/授权日:2002-10-31
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