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18 条记录 (耗时 0.032 秒)

    1,4-dihydropyridine compounds as bradykinin antagonists
    1.
    发明授权
    1,4-dihydropyridine compounds as bradykinin antagonists 失效
    1,4-二氢吡啶化合物作为缓激肽拮抗剂

    公开(公告)号：US06653313B2

    公开(公告)日：2003-11-25

    申请号：US09903157

    申请日：2001-07-11

    申请人： Mitsuhiro Kawamura ,  Makoto Kawai ,  Yuji Shishido ,  Tomoki Kato ,  Yasuhiro Katsu ,  Takafumi Ikeda ,  Noriaki Murase

    发明人： Mitsuhiro Kawamura ,  Makoto Kawai ,  Yuji Shishido ,  Tomoki Kato ,  Yasuhiro Katsu ,  Takafumi Ikeda ,  Noriaki Murase

    IPC分类号： A61K31496

    CPC分类号： A61K31/46 ,  A61K31/496 ,  C07D451/04 ,  Y02A50/411

    摘要： The present invention relates to compounds of the formula wherein each A is independently halo; Y is —(CH2)m—, —C(O)— or —S(O)—; R1 and R2 are independently C1-4 alkyl; R3 is substituted azacycloalkyl etc.; R4 is phenyl substituted at the 2-position with a substituent selected from substituted C1-7 alkyl, substituted C1-7 alkoxy, amine, etc; R5 is hydrogen or C1-4 alkyl; m is 0, 1 or 2; and n is 0, 1, 2, 3, 4 or 5. The present invention also relates to pharmaceutical compositions containing such compounds and to the use of such compounds in the treatment and prevention of inflammation, asthma, allergic rhinitis, pain and other disorders.

    摘要翻译： 本发明涉及各种化合物，每个A独立地是卤素; Y是 - （CH 2）m - ， - C（O） - 或-S（O） - ; R 1和R 2独立地是C 1-4烷基; R 3是取代的氮杂环烷基等; R 4是在2-位上被取代基取代的C 1-7烷基，取代的C 1-7烷氧基，胺等取代的苯基; R 5是氢或C 1-4烷基; m为0,1或2; 本发明还涉及含有这些化合物的药物组合物以及这些化合物在治疗和预防炎症，哮喘，变应性鼻炎，疼痛和其它疾病中的用途 。

    5-membered heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists
    2.
    发明授权
    5-membered heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists 失效
    5元杂芳基取代的1,4-二氢吡啶化合物作为缓激肽拮抗剂

    公开(公告)号：US06444677B2

    公开(公告)日：2002-09-03

    申请号：US09731995

    申请日：2000-12-07

    申请人： Takafumi Ikeda ,  Mitsuhiro Kawamura ,  Noriaki Murase ,  Seiji Nukui ,  Yuji Shishido ,  Makato Kawai ,  Yoshiyuki Okumura

    发明人： Takafumi Ikeda ,  Mitsuhiro Kawamura ,  Noriaki Murase ,  Seiji Nukui ,  Yuji Shishido ,  Makato Kawai ,  Yoshiyuki Okumura

    IPC分类号： C07D40100

    CPC分类号： C07D417/06 ,  C07D417/12 ,  C07D417/14

    摘要： This invention provides a compound of the formula (I): or the pharmaceutically acceptable salts thereof wherein A is independently halo; Y1 is —(CH2)m—, C(O) or S(O); Y2 is N or CH; R1 and R2 are independently C1-4 alkyl; R3 is selected from the following: (a) optionally substituted —(CH2)p—C3-7 cycloalkyl; (b) optionally substituted —C5-7 alkyl; and (c) substituted —C1-4 alkyl; and (d) optionally substituted C7-9 bicycloalkyl; R4 is optionally substituted thiazolyl, imidazolyl or oxazolyl; X is S, —NH, —N—C1-4 alkyl or O; R5 is hydrogen or C1-4 alkyl; R6 is C1-4 alkyl or halo; m is 0, 1 or 2; n is 0, 1, 2, 3, 4 or S; and p is 0, 1, 2, 3, 4, 5 or 6. These compounds are useful for the treatment of medical conditions caused by bradykinin such as inflammation, cardiovascular disease, pain, etc. This invention also provides a pharmaceutical composition comprising the above compound.

    摘要翻译： 本发明提供式（I）的化合物或其药学上可接受的盐，其中A独立地为卤素; Y1是 - （CH2）m-，C（O）或S（O）; Y2是N或CH; R1和R2独立地是C1-4烷基; R3选自如下：（a）任选取代的 - （CH 2）p -C 3-7环烷基;（b）任选取代的-C 5-7烷基; 和（c）取代的C 1-4烷基; 和（d）任选取代的C 7-9双环烷基; R 4是任选取代的噻唑基，咪唑基或恶唑基; X是S，-NH，-N-C 1-4烷基或O; R 5是氢或C 1-4烷基; R6是C1-4烷基或卤素; m是0,1或2; n为0，1，2，3，4或S; 并且p为0,1,2,3,4,5或6.这些化合物可用于治疗由缓激肽引起的疾病如炎症，心血管疾病，疼痛等。本发明还提供一种药物组合物，其包含 以上化合物。

    Optically active 1,4-dihydropyridine compounds as bradykinin antagonists
    3.
    发明授权
    Optically active 1,4-dihydropyridine compounds as bradykinin antagonists 失效
    光活性1,4-二氢吡啶化合物作为缓激肽拮抗剂

    公开(公告)号：US6156752A

    公开(公告)日：2000-12-05

    申请号：US133580

    申请日：1998-08-13

    申请人： Takafumi Ikeda ,  Mitsuhiro Kawamura ,  Yu-Ting Ge

    发明人： Takafumi Ikeda ,  Mitsuhiro Kawamura ,  Yu-Ting Ge

    IPC分类号： C07D487/04 ,  A61K31/4427 ,  A61K31/455 ,  A61K31/55 ,  A61P1/00 ,  A61P3/08 ,  A61P9/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/04 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P37/08 ,  A61P43/00 ,  C07D211/90 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D451/02 ,  C07D451/04 ,  C07D453/02 ,  C07D453/06 ,  A61K31/497

    CPC分类号： C07D451/04 ,  C07D211/90 ,  C07D401/06 ,  C07D401/12 ,  C07D453/06

    摘要： This invention provides a compound of the formula (I): ##STR1## and its pharmaceutically acceptable salts, wherein A.sup.1 and A.sup.2 are each halo; R.sup.1 and R.sup.2 are independently C.sub.1-4 alkyl; R.sup.3 is substituted or unsubstituted, phenyl or naphthyl; Y is heterocyclic group selected from C.sub.5-10 azacycloalkyl, C.sub.6-10 diazacycloalkyl, C.sub.7-10 azabicycloalkyl and the like; and R.sup.4 is selected from (a) substituted or unsubstituted C.sub.1-8 alkyll; (b) substituted or unsubstituted amino; (c) substituted or unsubstituted C.sub.2-6 alkanoyl; (d) substituted or unsubstituted C.sub.3-8 cycloalkyl or C.sub.7-14 bicycloalkyl; (e) substituted or unsubstituted C.sub.5-10 azacycloalkyl or C.sub.6-10 diazacycloalkyl, and (f) substituted or unsubstituted C.sub.7-14 mono- or di-azabicycloalkyl. These compounds are useful for the treatment of medical conditions caused by bradykinin such as inflammation, cardiovascular disease, pain, etc. This invention also provides a pharmaceutical composition comprising the above compound, and intermediates of the above compounds.

    摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，其中A1和A2各自为卤素; R1和R2独立地为C1-4烷基; R3是取代或未取代的，苯基或萘基; Y是选自C5-10氮杂环烷基，C6-10二氮杂环烷基，C7-10氮杂双环烷基等的杂环基; 并且R 4选自（a）取代或未取代的C 1-8烷基; （b）取代或未取代的氨基; （c）取代或未取代的C 2-6烷酰基; （d）取代或未取代的C 3-8环烷基或C 7-14双环烷基; （e）取代或未取代的C 5-10二氮杂环烷基或C 6-10二氮杂环烷基，和（f）取代或未取代的C 7-14单 - 或二 - 氮杂双环烷基。 这些化合物可用于治疗由缓激肽引起的疾病如炎症，心血管疾病，疼痛等。本发明还提供包含上述化合物的药物组合物和上述化合物的中间体。

    Shower head
    5.
    外观设计
    Shower head 有权

    公开(公告)号：USD1004745S1

    公开(公告)日：2023-11-14

    申请号：US29801694

    申请日：2021-07-30

    申请人： Mitsuhiro Kawamura

    设计人： Mitsuhiro Kawamura

    摘要： FIG. 1 is a perspective view of a shower head showing my new design;
    FIG. 2 is a front view thereof;
    FIG. 3 is a rear view thereof;
    FIG. 4 is a top plan view thereof;
    FIG. 5 is a bottom plan view thereof;
    FIG. 6 is a left side view thereof; and,
    FIG. 7 is a right side view thereof.
    Broken lines illustrate portions of the shower head that form no part of the claimed design.

    Method of measuring unsaturated inductances of an equivalent circuit of a synchronous machine
    6.
    发明授权
    Method of measuring unsaturated inductances of an equivalent circuit of a synchronous machine 失效
    测量同步电机等效电路不饱和电感的方法

    公开(公告)号：US5309089A

    公开(公告)日：1994-05-03

    申请号：US928347

    申请日：1992-08-12

    申请人： Mitsuhiro Kawamura

    发明人： Mitsuhiro Kawamura

    IPC分类号： G01R31/34 ,  G01R27/26 ,  H02K19/36 ,  H02P27/06

    CPC分类号： G01R27/2611

    摘要： A method of measuring unsaturated inductances of an equivalent circuit of a synchronous machine including measuring a no-load saturation characteristic of a synchronous machine; measuring a three-phase short-circuit characteristic of the synchronous machine; measuring currents and voltages of an armature and a field when an armature coil and a field coil are in a positional relationship wherein a magnetomotive force by flowing current to the armature coil of the synchronous machine becomes a direct-axis magnetomotive force and both when the field coil is in an open-circuit state and when the field coil is in a short-circuit state by direct-axis Dalton-Cameron method; and solving simultaneous equations concerning a direct-axis equivalent circuit of the synchronous machine by using results of the measuring the no-load saturation characteristic, the measuring the three-phase short-circuit characteristic and the measuring by the direct-axis Dalton-Cameron method, thereby obtaining impedances of respective elements constituting the direct-axis equivalent circuit.

    摘要翻译： 一种测量同步电机的等效电路的不饱和电感的方法，包括测量同步电机的空载饱和特性; 测量同步电机的三相短路特性; 当电枢线圈和励磁线圈处于位置关系时，测量电枢和场的电流和电压，其中通过流向同步电机的电枢线圈的电流的磁动势变为直轴磁动势，并且当场 线圈处于开路状态，当励磁线圈通过直轴道尔顿 - 卡梅伦方法处于短路状态时; 并通过使用测量空载饱和特性的结果，测量三相短路特性和通过直轴道尔顿 - 卡梅伦方法测量的方法来解决同步电机的直轴等效电路的联立方程 从而获得构成直轴等效电路的各元件的阻抗。

    Shower head
    8.
    外观设计
    Shower head 有权

    公开(公告)号：USD1004746S1

    公开(公告)日：2023-11-14

    申请号：US29801696

    申请日：2021-07-30

    申请人： Mitsuhiro Kawamura

    设计人： Mitsuhiro Kawamura

    摘要： FIG. 1 is a perspective view of a shower head showing my new design;
    FIG. 2 is a front view thereof;
    FIG. 3 is a rear view thereof;
    FIG. 4 is a top plan view thereof;
    FIG. 5 is a bottom plan view thereof;
    FIG. 6 is a left side view thereof; and,
    FIG. 7 is a right side view thereof.
    Broken lines illustrate portions of the shower head that form no part of the claimed design.

    Rotating electrical machine
    9.
    发明授权
    Rotating electrical machine 有权
    旋转电机

    公开(公告)号：US09559557B2

    公开(公告)日：2017-01-31

    申请号：US14131093

    申请日：2011-08-11

    申请人： Toshihiro Tsuda ,  Mitsuhiro Kawamura ,  Tadashi Fukami ,  Kazuo Shima

    发明人： Toshihiro Tsuda ,  Mitsuhiro Kawamura ,  Tadashi Fukami ,  Kazuo Shima

    IPC分类号： H02K3/16 ,  H02K19/10 ,  H02K3/28 ,  H02K3/46 ,  H02K19/06 ,  H02K3/20 ,  H02K19/20 ,  H02K3/00 ,  H02K7/18

    CPC分类号： H02K3/16 ,  H02K3/00 ,  H02K3/20 ,  H02K3/28 ,  H02K3/46 ,  H02K7/1838 ,  H02K19/06 ,  H02K19/10 ,  H02K19/20 ,  H02K2213/03

    摘要： This rotating electrical machine has a rotor, stator core, field windings for multiple poles, and armature windings for the multiple poles. The rotor is rotatably supported about a shaft. Convex-shaped multiple salient pole sections are formed on the outer circumference of the rotor while arranged in the circumferential direction. The stator core is provided along the outer circumference of the rotor with an air gap from the rotor. Convex-shaped multiple teeth are formed on the inner circumference of the stator core while arranged in the circumferential direction. The field windings for the multiple poles are wound around each of the multiple teeth while insulated from the field windings.

    摘要翻译： 该旋转电机具有转子，定子芯，多极的励磁绕组和多极的电枢绕组。 转子围绕轴可旋转地支撑。 在圆周方向上布置有转子的外周上形成凸形的多个凸极部。 定子芯沿着转子的外圆周设置有来自转子的气隙。 在圆周方向上布置有定子芯的内圆周上形成有凸形的多个齿。 多极的励磁绕组缠绕在多个齿的每一个上，同时与励磁绕组绝缘。