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US06653478B2 Substituted benzimidazol-2-ones as vasopressin receptor antagonists and neuropeptide Y modulators 失效
取代的苯并咪唑-2-酮作为血管加压素受体拮抗剂和神经肽Y调节剂

Substituted benzimidazol-2-ones as vasopressin receptor antagonists and neuropeptide Y modulators
Abstract:
The invention is directed to substituted benzimidazol-2-ones of Formula I, wherein A, X, Y, m, n, R1, R2, R3, R4, and R5 are as described in the specification, which are useful as vasopressin receptor antagonists or Neuropeptide Y Modulators for treating conditions such as aggression, obsessive-compulsive disorders, hypertension, dysmenorrhea, congestive heart failure/cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, edema, ischemia, stroke, thrombosis, water retention, nephrotic syndrome, central nervous injuries, obesity, anorexia, hyperglycemia, diabetes, anxiety, depression, asthma, memory loss, sexual dysfunction, disorders of sleep and other circadian rhythms, and Cushing's disease.
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