公开(公告)号：US06653478B2

公开(公告)日：2003-11-25

申请号：US10047841

申请日：2001-10-23

Applicant: Maud J. Urbanski ,  Joseph W. Gunnet, Jr. ,  Keith T. Demarest

Inventor： Maud J. Urbanski ,  Joseph W. Gunnet, Jr. ,  Keith T. Demarest

IPC: C07D40104

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

Abstract: The invention is directed to substituted benzimidazol-2-ones of Formula I, wherein A, X, Y, m, n, R1, R2, R3, R4, and R5 are as described in the specification, which are useful as vasopressin receptor antagonists or Neuropeptide Y Modulators for treating conditions such as aggression, obsessive-compulsive disorders, hypertension, dysmenorrhea, congestive heart failure/cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, edema, ischemia, stroke, thrombosis, water retention, nephrotic syndrome, central nervous injuries, obesity, anorexia, hyperglycemia, diabetes, anxiety, depression, asthma, memory loss, sexual dysfunction, disorders of sleep and other circadian rhythms, and Cushing's disease.

Abstract translation: 本发明涉及式I的取代的苯并咪唑-2-酮，其中A，X，Y，m，n，R 1，R 2，R 3，R 4和R 5如说明书中所述，其可用作加压素受体拮抗剂 或神经肽Y调节剂，用于治疗诸如侵略，强迫症，高血压，痛经，充血性心力衰竭/心脏功能不全，冠状动脉血管痉挛，心脏缺血，肝硬化，肾血管痉挛，肾衰竭，水肿，缺血，中风，血栓形成， 保水性，肾病综合征，中枢神经损伤，肥胖症，厌食症，高血糖症，糖尿病，焦虑症，抑郁症，哮喘，记忆丧失，性功能障碍，睡眠障碍和其他昼夜节律以及库欣氏病。