Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals

发明授权

US06669943B1 Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals 有权

标题翻译：具有改变的干扰素拮抗剂活性的减毒负链病毒用作疫苗和药物

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专利标题： Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals
专利标题（中）： 具有改变的干扰素拮抗剂活性的减毒负链病毒用作疫苗和药物
申请号： US09332288

申请日： 1999-06-11
公开(公告)号： US06669943B1

公开(公告)日： 2003-12-30
发明人: Peter Palese , Adolfo Garcia-Sastre , Thomas Muster
申请人： Peter Palese , Adolfo Garcia-Sastre , Thomas Muster
主分类号： A61K39145
IPC分类号： A61K39145

Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals

摘要：

The present invention relates, in general, to attenuated negative-strand RNA viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. The invention also relates to the development and use of IFN-deficient systems for selection of such attenuated viruses. In particular, the invention relates to attenuated influenza viruses having modifications to the NS1 gene that diminish or eliminate the ability of the NS1 gene product to antagonize the cellular IFN response. The mutant viruses replicate in vivo but demonstrate reduced pathogenicity, and therefore are well suited for live virus vaccines, and pharmaceutical formulations.

摘要（中）：

本发明一般涉及具有拮抗细胞干扰素（IFN）应答能力受损的减毒负链RNA病毒，以及在疫苗和药物制剂中使用这种减毒病毒。本发明还涉及用于选择这种减毒病毒的IFN缺陷系统的开发和使用。特别地，本发明涉及具有NS1基因修饰的减毒或消除NS1基因产物拮抗能力的减毒流感病毒细胞IFN反应。突变体病毒在体内复制但表现出降低的致病性，因此非常适合于活病毒疫苗和药物制剂。

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