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    Recombinant influenza viruses and uses thereof
    1.
    发明授权
    Recombinant influenza viruses and uses thereof 有权
    重组流感病毒及其用途

    公开(公告)号：US09217157B2

    公开(公告)日：2015-12-22

    申请号：US13387293

    申请日：2010-07-27

    申请人： Adolfo Garcia-Sastre ,  Peter Palese ,  Balaji Manicassamy

    发明人： Adolfo Garcia-Sastre ,  Peter Palese ,  Balaji Manicassamy

    IPC分类号： A61K39/145 ,  C12N7/04 ,  C12N15/44 ,  A61K39/12 ,  C12N7/01 ,  A61K39/00 ,  C12N15/86 ,  C07K14/005 ,  C12N7/00

    CPC分类号： C12N15/86 ,  C07K14/005 ,  C07K2319/50 ,  C07K2319/60 ,  C12N7/00 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16143

    摘要： Modified influenza virus NS gene segments and nucleic acid sequences encoding such modified influenza virus NS gene segments are described. In certain embodiments, a modified influenza virus NS gene segment comprises an influenza virus NS 1 open reading frame (ORF) lacking a stop codon, a heterologous nucleotide sequence, a 2A autoproteolytic cleavage site or another cleavage site, an NEP ORF, wherein the gene segment has one or more mutations in either the splice acceptor site, splice donor site, or both the splice acceptor and splice donor sites that prevents splicing of mRNA. Also recombinant influenza viruses comprising a modified influenza virus NS gene segment and the use of such viruses are described. The recombinant influenza viruses may be used in the prevention and/or treatment of influenza virus disease or as a delivery vector.

    摘要翻译： 描述了修饰的流感病毒NS基因片段和编码这种修饰的流感病毒NS基因片段的核酸序列。 在某些实施方案中，修饰的流感病毒NS基因片段包含缺乏终止密码子，异源核苷酸序列，2A自体蛋白水解切割位点或另一切割位点的流感病毒NS1开放阅读框（ORF），NEP ORF，其中所述基因 片段在剪接受体位点，剪接供体位点，或剪接受体和剪接供体位点都有一个或多个突变，其阻止mRNA的剪接。 还描述了包含修饰的流感病毒NS基因片段的重组流感病毒和这种病毒的使用。 重组流感病毒可用于预防和/或治疗流感病毒病或作为递送载体。

    RECOMBINANT NEGATIVE STRAND VIRUS RNA EXPRESSION SYSTEMS AND VACCINES
    2.
    发明申请
    RECOMBINANT NEGATIVE STRAND VIRUS RNA EXPRESSION SYSTEMS AND VACCINES 审中-公开
    重组阴性条纹病毒RNA表达系统和疫苗

    公开(公告)号：US20140363878A1

    公开(公告)日：2014-12-11

    申请号：US14203743

    申请日：2014-03-11

    申请人： Adolfo Garcia-Sastre ,  Peter Palese

    发明人： Adolfo Garcia-Sastre ,  Peter Palese

    IPC分类号： C12N7/00

    CPC分类号： C12N7/00 ,  A61K48/00 ,  A61K2039/5256 ,  C07K14/005 ,  C12N15/86 ,  C12N2760/00034 ,  C12N2760/18122 ,  C12N2760/18143 ,  C12N2830/00 ,  C12N2830/60

    摘要： The present invention relates to recombinant RNA virus templates derived from and applicable to negative strand naturally non-segmented viruses, including the families Bornaviridae, Filoviridae, and Paramyxoviridae, and methods for generating such recombinant RNA virus templates, wherein the templates are generated from two or more recombinant RNA molecules. The invention relates to the use of segmented recombinant RNA virus templates for naturally non-segmented RNA viruses to express heterologous gene products in appropriate host cell systems and/or to construct recombinant viruses taken from that family and that express, package, and/or present the heterologous gene product. The invention includes the expression products and recombinant and chimeric viruses thus prepared and vaccine and therapeutic formulations comprising the recombinant RNA viruses.

    摘要翻译： 本发明涉及衍生自和适用于负链天然非分段病毒的重组RNA病毒模板，包括家族病毒科，病毒科和副粘病毒科，以及产生此类重组RNA病毒模板的方法，其中模板由两个或 更多的重组RNA分子。 本发明涉及分段重组RNA病毒模板在天然非分段RNA病毒中的用途，以在合适的宿主细胞系统中表达异源基因产物和/或构建从该家族获取的重组病毒，并表达，包装和/或呈递 异源基因产物。 本发明包括如此制备的表达产物和重组和嵌合病毒以及包含重组RNA病毒的疫苗和治疗剂型。

    Compounds that modulate negative-sense, single-stranded RNA virus replication and uses thereof
    4.
    发明授权
    Compounds that modulate negative-sense, single-stranded RNA virus replication and uses thereof 有权
    调节负义单链RNA病毒复制的化合物及其用途

    公开(公告)号：US08629283B2

    公开(公告)日：2014-01-14

    申请号：US12921077

    申请日：2009-03-06

    申请人： Megan L. Shaw ,  Hans-Heinrich Hoffmann ,  Adolfo Garcia-Sastre ,  Peter Palese

    发明人： Megan L. Shaw ,  Hans-Heinrich Hoffmann ,  Adolfo Garcia-Sastre ,  Peter Palese

    IPC分类号： C07D271/113

    CPC分类号： C07D271/113 ,  A61K31/00 ,  A61K31/4245

    摘要： The present invention relates to compounds that modulate the replication of negative-sense, single-stranded RNA viruses, such as influenza virus, and the use of such compounds. The invention relates to methods for increasing the titer of negative-sense, single-stranded RNA viruses, such as influenza virus, in substrates for virus propagation (e.g., tissue culture). The invention also relates to the use of compounds that decrease virus replication as antiviral agents. The invention further relates to methods for identifying compounds that modulate the replication of negative-sense, single-stranded RNA viruses, in particular, influenza virus.

    摘要翻译： 本发明涉及调节负义单链RNA病毒如流感病毒复制的化合物，以及这些化合物的用途。 本发明涉及用于在用于病毒繁殖（例如组织培养）的底物中增加负义的单链RNA病毒如流感病毒的滴度的方法。 本发明还涉及减少病毒复制作为抗病毒剂的化合物的用途。 本发明还涉及用于鉴定调节负义的单链RNA病毒，特别是流感病毒的复制的化合物的方法。