发明授权
US06670400B1 Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said derivatives
失效
对5-HT1A受体具有高亲和力的苯氧基乙胺衍生物，其制备，作为药物的用途，以及含有所述衍生物的药物组合物
- 专利标题： Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said derivatives
- 专利标题（中）： 对5-HT1A受体具有高亲和力的苯氧基乙胺衍生物，其制备，作为药物的用途，以及含有所述衍生物的药物组合物
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申请号： US08930379申请日： 2002-04-08
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公开(公告)号： US06670400B1公开(公告)日： 2003-12-30
- 发明人: Dennis Bigg , Jacques Pommier , Christiane Martin , Pierre Roubert , Jean Pierre Defaux
- 申请人： Dennis Bigg , Jacques Pommier , Christiane Martin , Pierre Roubert , Jean Pierre Defaux
- 优先权： GB9507288 19950407
- 主分类号： A61K31165
- IPC分类号： A61K31165
摘要：
Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as gastric acid secretion inhibitors or as antiemetics, are disclosed. In general formula (I), Ar is phenyl substituted by one or more substituents; and R is a C1-10 hydrocarbon radical selected from straight or branched alkyl, alkenyl or alkynyl radicals, saturated or unsaturated mono- or polycyclic cycloalkyl, cycloalkylalkyl or alkylcycloalkyl radicals; a pyridyl or isoquinolyl radical, phenyl optionally substituted by one or more substituents, and salts thereof.
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