发明授权
US06673776B1 Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human
失效
外源多核苷酸序列在脊椎动物，哺乳动物，鱼类，鸟类或人类中的表达
- 专利标题： Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human
- 专利标题（中）： 外源多核苷酸序列在脊椎动物，哺乳动物，鱼类，鸟类或人类中的表达
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申请号： US08481932申请日： 1995-06-07
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公开(公告)号： US06673776B1公开(公告)日： 2004-01-06
- 发明人: Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
- 申请人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
- 主分类号： A01N4304
- IPC分类号： A01N4304
摘要：
A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
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