发明授权
- 专利标题: Recombinant baculoviruses producing insect toxins
- 专利标题(中): 产生昆虫毒素的重组杆状病毒
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申请号: US08472053申请日: 1995-06-06
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公开(公告)号: US06689356B1公开(公告)日: 2004-02-10
- 发明人: Eliahu Zlotkin , Susumu Maeda , Billy Fred McCutchen , Bruce D. Hammock , Elizabeth Fowler , Rama M. Belagaje
- 申请人: Eliahu Zlotkin , Susumu Maeda , Billy Fred McCutchen , Bruce D. Hammock , Elizabeth Fowler , Rama M. Belagaje
- 主分类号: A61K4800
- IPC分类号: A61K4800
摘要:
A recombinant baculovirus is provided with a genetic coding sequence for the production of a foreign protein that is toxic to insects. Preferred are nuclear polyhedrosis viruses, with preferred embodiments having been constructed and expressed in insect cells: BmNPV.AaIT and AcNPV.AaIT. Both embodiments function in insect cells infected therewith so as to have the toxin AaIT (originating from the venom of the scorpion A. australis) secreted. A clone designated (pCIB4223), which contains the Bombyx mori signal sequence fused to the AaIT sequence, has been deposited with the American type culture collection and designated “ATCC 40906.”
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