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69 条记录 (耗时 0.049 秒)

    Insect control method with genetically engineered biopesticides
    2.
    发明授权
    Insect control method with genetically engineered biopesticides 失效
    基因工程生物农药的昆虫控制方法

    公开(公告)号：US06344193B1

    公开(公告)日：2002-02-05

    申请号：US09206766

    申请日：1998-01-15

    申请人： Bruce D. Hammock ,  Billy Fred McCutchen

    发明人： Bruce D. Hammock ,  Billy Fred McCutchen

    IPC分类号： A01N6300

    CPC分类号： C12N15/86 ,  A01N63/00 ,  C12N2710/14143 ,  A01N2300/00

    摘要： Insect pests can be controlled by treating the pests or their loci with a combination of recombinant virus and organic insecticide. The recombinant virus preferably is a baculovirus. Combinations of recombinant baculovirus with chemical insecticides provide a dose-response in pests, such as insects, that is greater than additive. Preferred treatments of the invention are uses of recombinant baculoviruses that express a foreign protein or toxin, with pyrethroid insecticides. Treatments against pyrethroid resistant pests are especially useful.

    摘要翻译： 可以通过用重组病毒和有机杀虫剂的组合处理害虫或其基因座来控制昆虫害虫。 重组病毒优选为杆状病毒。 重组杆状病毒与化学杀虫剂的组合在害虫（如昆虫）中提供大于添加剂的剂量反应。 本发明的优选处理是用拟除虫菊酯杀虫剂表达外源蛋白或毒素的重组杆状病毒的用途。 对拟除虫菊酯抗性害虫的治疗特别有用。

    Nucleic acids encoding plant inhibitors of apoptosis and transgenic cells and plants expressing them
    4.
    发明授权
    Nucleic acids encoding plant inhibitors of apoptosis and transgenic cells and plants expressing them 失效
    编码植物抑制剂的核酸和表达它们的转基因细胞和植物

    公开(公告)号：US06570069B1

    公开(公告)日：2003-05-27

    申请号：US09502528

    申请日：2000-02-10

    申请人： Bruce D. Hammock ,  Qihong Huang ,  Susumu Maeda

    发明人： Bruce D. Hammock ,  Qihong Huang ,  Susumu Maeda

    IPC分类号： A01H500

    CPC分类号： C12N15/8263 ,  C07K14/43563 ,  C07K14/4747 ,  C12N2799/026

    摘要： The present invention is generally directed to Inhibitor of Apoptosis Proteins (“IAPs”), nucleic acid molecules encoding IAPs, viral vectors, recombinant baculoviruses comprising an IAP, transgenic plants comprising an IAP nucleic acid, and methods of assaying for compounds which bind to an IAP. In general, the IAP nucleic acids of the invention have 95% or higher identity to SEQ ID NO:1 and the IAP of the invention have 90% or higher identity to SEQ ID NO:3.

    摘要翻译： 本发明一般涉及凋亡蛋白（“IAP”）抑制剂，编码IAP的核酸分子，病毒载体，包含IAP的重组杆状病毒，包含IAP核酸的转基因植物，以及测定与 IAP。 通常，本发明的IAP核酸与SEQ ID NO：1具有95％或更高的同一性，并且本发明的IAP与SEQ ID NO：3具有90％或更高的同一性。

    Reducing nephropathy with inhibitors of soluble epoxide hydrolase and epoxyeicosanoids
    9.
    发明授权
    Reducing nephropathy with inhibitors of soluble epoxide hydrolase and epoxyeicosanoids 有权
    用可溶性环氧化物水解酶和环氧类别的抑制剂减少肾病

    公开(公告)号：US08513302B2

    公开(公告)日：2013-08-20

    申请号：US13100978

    申请日：2011-05-04

    申请人： Bruce D. Hammock ,  Takaho Watanabe ,  Seung-Jin Ma ,  Susan E. Bennett ,  Judith S. Stern ,  Christophe Morisseau ,  In-Hae Kim

    发明人： Bruce D. Hammock ,  Takaho Watanabe ,  Seung-Jin Ma ,  Susan E. Bennett ,  Judith S. Stern ,  Christophe Morisseau ,  In-Hae Kim

    IPC分类号： A61K31/17 ,  A61K31/16

    CPC分类号： A61K31/70 ,  A61K31/17 ,  A61K31/355

    摘要： The invention provides uses and methods for reducing nephropathy in persons with diabetes mellitus (particularly Type 2 diabetes), in persons with metabolic syndrome, in persons with triglyceride levels over 215 mg/dL, and in persons with a cholesterol level over 200 mg/dL, by administering an inhibitor of soluble epoxide hydrolase (“sEH”). Optionally, a cis-epoxyeicosantrienoic acid (“EET”) can be administered with the sEH inhibitor. The invention further provides for using EETs in conjunction with one or more sEH inhibitors to reduce hypertension, and for compositions of EETs coated with a material insoluble in an acid of pH 3 but soluble in a solution with a pH of 7.4 or higher.

    摘要翻译： 本发明提供了在甘油三酯水平超过215mg / dL的人中以及胆固醇水平超过200mg / dL的人中减少糖尿病患者（特别是2型糖尿病）患有代谢综合征患者的肾病的用途和方法 ，通过施用可溶性环氧化物水解酶（“sEH”）的抑制剂。 任选地，顺式 - 环氧二十碳三烯酸（“EET”）可与sEH抑制剂一起施用。 本发明进一步提供使用EET与一种或多种sEH抑制剂联合以降低高血压，以及用不溶于pH 3但可溶于pH 7.4或更高的溶液的材料涂覆的EET组合物。