Invention Grant
- Patent Title: Pyrazine derivatives as modulators of tyrosine kinases
- Patent Title (中): 吡嗪衍生物作为酪氨酸激酶的调节剂
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Application No.: US09955780Application Date: 2001-09-19
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Publication No.: US06710048B2Publication Date: 2004-03-23
- Inventor: Gee-Hong Kuo , Peter J. Connolly , Catherine Prouty , Alan DeAngelis , Aihua Wang , Linda Jolliffe , Steve Middleton , Stuart Emanuel
- Applicant: Gee-Hong Kuo , Peter J. Connolly , Catherine Prouty , Alan DeAngelis , Aihua Wang , Linda Jolliffe , Steve Middleton , Stuart Emanuel
- Main IPC: A61K31505
- IPC: A61K31505
Abstract:
The present invention provides pyrazine derivatives that inhibit tyrosine kinase activity. Certain pyrazine derivatives are selective inhibitors of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. The present invention also provides pharmaceutical formulations containing the pyrazine derivatives and methods of use of these formulations as anti-tumor agents and to treat solid-tumor cancers, angiogenesis, diabetic retinopathy, rheumatoid arthritis, endometriosis and psoriasis.
Public/Granted literature
- US20030060629A1 Pyrazine derivatives as modulators of tyrosine kinases Public/Granted day:2003-03-27
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