A high field asymmetric waveform ion mobility spectrometer (FAIMS) having spherical electrode geometry is disclosed. The spherical FAIMS includes an inner generally spherical electrode supported in a spaced-apart arrangement relative to an outer electrode. The outer electrode has a curved inner surface that maintains an approximately uniform spacing to the inner electrode. The space between the inner and outer electrodes defines an analyzer region, where an electric field is established by the application of an asymmetric waveform voltage and a direct current compensation voltage to at least one of the inner and outer electrodes. An ion inlet and an ion outlet are disposed within the curved inner surface of the outer electrode such that the shortest distance between the inlet and the outlet in any direction around the inner electrode is approximately a same distance.