发明授权
US06716851B2 Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof
失效
取代的2-芳基-4-芳基氨基嘧啶和类似物作为活化剂或胱天蛋白酶和凋亡诱导剂及其用途
- 专利标题： Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof
- 专利标题（中）： 取代的2-芳基-4-芳基氨基嘧啶和类似物作为活化剂或胱天蛋白酶和凋亡诱导剂及其用途
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申请号： US10012444申请日： 2001-12-12
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公开(公告)号： US06716851B2公开(公告)日： 2004-04-06
- 发明人: Sui Xiong Cai , John A. Drewe , Bao Nguyen , Azra Pervin
- 申请人： Sui Xiong Cai , John A. Drewe , Bao Nguyen , Azra Pervin
- 主分类号： A61K31505
- IPC分类号： A61K31505
摘要：
The present invention is directed to substituted 2-aryl-4-arylaminopyrimidine and analogs thereof, represented by the general Formula I: wherein A, Ar1, Ar2, R1 and R3 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.