摘要:
The present invention is directed to substituted 2-aryl-4-arylaminopyrimidine and analogs thereof, represented by the general Formula I: wherein A, Ar1, Ar2, R1 and R3 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要:
The present invention is directed to substituted 2-aryl-4-arylaminopyrimidine and analogs thereof, represented by the general Formula I: wherein A, Ar1, Ar2, R1 and R3 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要:
The present invention is directed to substituted 2-arylmethylene-N-aryl-N′-aryl-malonamides and analogs thereof. The present invention also relates to the discovery that the compounds are activators of caspases and inducers of apoptosis. Therefore, the activators os caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要:
The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.
摘要:
A method and apparatus to perform persistence tests for a mobile station in a network are described. The apparatus includes a random number generator, a timer module, and a processor coupled to the random number generator and the timer module. A counter for the random number generator configured to count access slots is initialized. One or more random numbers are successively generated, until a value of a generated random number is lower than a first predetermined value. At the same time, the counter is successively incremented based on the number of generated random numbers. When the counter value is higher than or equal to a second predetermined value of successive iterations, or, in the alternative, when the value of the generated random number is lower than the first predetermined value, the mobile station is deactivated for a predetermined number of access slots equal to the counter value. A timer interrupt further runs subsequent to the expiration of the predetermined number of access slots. Finally, if an access probe needs to be transmitted to the network, the timer interrupt is disabled and a random access number is generated in preparation for transmission of the access probe to enable access to the network.
摘要:
A cable management device for managing cables extending between a support rack and an object slideable in and out of the support rack includes a support having a stop member and a mounting surface that is removably fastenable to the support rack. A first elongate member extends between a proximal end and a distal end and is pivotably fastened to the support at the proximal end. A second elongate member extends between a proximal end and a distal end, the proximal end of the second elongate member pivotably fastened to the distal end of the first elongate member. The first and second elongate members are movable from a folded position where the elongate members are substantially adjacent each other to an unfolded position, wherein the stop member limits the rotation of the first elongate member between the folded and unfolded positions to about ninety degrees.
摘要:
A first device receives a message over a wired connection from a second device seeking to establish a secure wireless connection with the first device. In response to the received message, the first device exchanges information with the second device and automatically selects a wireless connection configuration. The first device then sends wireless connection information, including information identifying at least a portion of the wireless connection configuration, to the second device over the wired connection. The wireless connection with the second device is enabled in accordance with the selected wireless connection configuration.
摘要:
A tooth whitening apparatus and method using an intra-oral light generating device, whereas the light generating device is placed inside a patient's mouth and bucally to the jaws to produce a light source, comprises the steps of applying inside a means for depositing and applying, adapted for the upper and lower jaws, a tooth whitening agent comprising an optical chemical agent. Said means for depositing and applying are made of suitable material comprising plastic, and adapted inside the patient's mouth and adjacent to the inner surface of the patient's lips. The method further includes the steps of placing the means for depositing and applying filled with a light-activated, tooth whitening agent into the patient's mouth, onto the corresponding jaws and positioning the light generating device, inside the patient's mouth, bucally to the jaws, whereas the intra-oral light is located adjacent to surface of the means for depositing-and-applying, and on the inner surface of the cheeks and lips of the mouth of said patient. Therein the intra-oral light activates the tooth whitening agent for a period of time.
摘要:
Reduced delays in data service offered by data-capable networks are provided. One illustrative method includes the steps of receiving and storing in memory a first timer value which is broadcasted by a wireless communication network for use in the mobile station; causing a request for data connectivity to be transmitted through the wireless network, and reattempting the request up to a plurality of times when data connectivity fails; after the one or more reattempted requests for data connectivity fail, activating a timer based on a second timer value which is less than the first timer value; and repeating the transmitting of requests for data connectivity after expiration of the timer.
摘要:
Embodiments of the present invention provide a method, system, and computer program product for validating a computer environment. In an embodiment of the invention, a signature file denoting the infrastructure requirements of a computing environment to support a computer program to be installed in the computer environment of multiple different computing devices disposed in multiple different network domains can be loaded. Administrative network privileges to access the multiple different network domains in the computing environment can be acquired. Further, at least one deficiency in the infrastructure requirements corresponding to one of the network domains can be identified and the identified deficiency can be remediated. The identified deficiency can be reported.