Invention Grant
US06723724B2 Isoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 or D4 receptor, and preparation thereof
失效
在多巴胺D3或D4受体上具有选择性生物活性的异恶唑基烷基哌嗪衍生物及其制备
- Patent Title: Isoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 or D4 receptor, and preparation thereof
- Patent Title (中): 在多巴胺D3或D4受体上具有选择性生物活性的异恶唑基烷基哌嗪衍生物及其制备
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Application No.: US09839206Application Date: 2001-04-23
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Publication No.: US06723724B2Publication Date: 2004-04-20
- Inventor: Hun Yeong Koh , Kyung Il Choi , Yong Seo Cho , Ae Nim Pae , Kyung Ho Kang , Mi Young Cha , Jae Yang Kong , Dae Young Jeong , Hee-Yoon Lee
- Applicant: Hun Yeong Koh , Kyung Il Choi , Yong Seo Cho , Ae Nim Pae , Kyung Ho Kang , Mi Young Cha , Jae Yang Kong , Dae Young Jeong , Hee-Yoon Lee
- Priority: KR2000-73121 20001204
- Main IPC: A61K31496
- IPC: A61K31496
Abstract:
The present invention relates to isoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 or D4 receptors represented by the following formula (1), and its preparation method through reductive amination reaction in the presence of reducing agent, wherein R1, R2, X and n are the same as defined in the specification.
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