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23 条记录 (耗时 0.018 秒)

    Compositions and methods for selective inhibition of nicotine acetylcholine receptors
    1.
    发明授权
    Compositions and methods for selective inhibition of nicotine acetylcholine receptors 有权
    用于选择性抑制尼古丁乙酰胆碱受体的组合物和方法

    公开(公告)号：US08980923B2

    公开(公告)日：2015-03-17

    申请号：US13526076

    申请日：2012-06-18

    申请人： Roger L. Papke ,  Nicole A. Horenstein ,  Michael M. Francis ,  Kyung Il Choi

    发明人： Roger L. Papke ,  Nicole A. Horenstein ,  Michael M. Francis ,  Kyung Il Choi

    IPC分类号： A61K31/4465 ,  C07D211/44

    CPC分类号： C07D211/44

    摘要： The present invention concerns methods for treating or preventing neurological disorders characterized by dysfunction of nicotinic acetylcholine receptors by administering 2,2,6,6-tetramethylpiperidin-4-yl heptanoate (TMPH), or a pharmaceutically acceptable salt thereof, to the patient. In another aspect, the present invention pertains to pharmaceutical compositions containing TMPH, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. In another aspect, the present invention pertains to methods for selectively inhibiting nicotinic acetylcholine receptors that lack an α5, α6, or β3 subunit by contacting an effective amount of TMPH, or a pharmaceutically acceptable salt thereof, to the receptor. The method for selectively inhibiting nicotinic acethylcholine receptors that lack an α5 subunit can be carried out in vivo or in vitro.

    摘要翻译： 本发明涉及通过向患者施用2,2,6,6-四甲基哌啶-4-基庚酸酯（TMPH）或其药学上可接受的盐来治疗或预防特征为烟碱乙酰胆碱受体功能障碍的神经障碍的方法。 另一方面，本发明涉及含有TMPH或其药学上可接受的盐和药学上可接受的载体的药物组合物。 另一方面，本发明涉及通过使有效量的TMPH或其药学上可接受的盐与受体接触来选择性地抑制缺乏α5，α6或αb亚基的烟碱乙酰胆碱受体的方法。 选择性抑制缺乏α5亚基的烟碱型乙酰胆碱受体的方法可以在体内或体外进行。

    Method for manufacturing cleaner fuels
    7.
    发明授权
    Method for manufacturing cleaner fuels 有权
    制造清洁燃料的方法

    公开(公告)号：US06248230B1

    公开(公告)日：2001-06-19

    申请号：US09339639

    申请日：1999-06-24

    申请人： Wha-Sik Min ,  Kyung-Il Choi ,  Sin-Young Khang ,  Dong-Soon Min ,  Jae-Wook Ryu ,  Kwan-Sik Yoo ,  Jyu-Hwan Kim

    发明人： Wha-Sik Min ,  Kyung-Il Choi ,  Sin-Young Khang ,  Dong-Soon Min ,  Jae-Wook Ryu ,  Kwan-Sik Yoo ,  Jyu-Hwan Kim

    IPC分类号： C10G6704

    CPC分类号： C10G67/06 ,  C10G67/04

    摘要： A method is provided for manufacturing cleaner fuels, in which NPC (Natural Polar Compounds), naturally existing in small quantities within various petrolic hydrocarbon fractions, are removed from the petrolic hydrocarbon fractions ranging, in boiling point, from 110 to 560° C. and preferably from 200 to 400° C., in advance of catalytic hydroprocessing. The removal of NPC improves the efficiency of the catalytic process and produces environment-friendly products, such as diesel fuel with a sulfur content of 50 ppm (wt) or lower. Also, the NPC can be used to improve fuel lubricity.

    摘要翻译： 提供了一种用于制造清洁燃料的方法，其中在各种石油烃馏分中天然存在少量的NPC（天然极性化合物）从沸点为110-560℃的石油烃馏分中除去， 优选为200-400℃，在催化加氢处理之前。 NPC的去除提高了催化过程的效率，并且生产了环境友好的产品，例如硫含量为50ppm（wt）或更低的柴油燃料。 此外，NPC可用于提高燃油润滑性。