发明授权
US06737264B1 Method for purifying and isolating (2s,3s)- or (2r,3s)-halohydrin derivatives
失效
纯化和分离(2s,3s) - 或(2r,3s) - 卤代醇衍生物的方法
- 专利标题: Method for purifying and isolating (2s,3s)- or (2r,3s)-halohydrin derivatives
- 专利标题(中): 纯化和分离(2s,3s) - 或(2r,3s) - 卤代醇衍生物的方法
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申请号: US09869297申请日: 2001-11-02
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公开(公告)号: US06737264B1公开(公告)日: 2004-05-18
- 发明人: Katsuji Maehara , Shigeru Kawano , Makoto Yamaguchi , Yasuyoshi Ueda
- 申请人: Katsuji Maehara , Shigeru Kawano , Makoto Yamaguchi , Yasuyoshi Ueda
- 优先权: JP11/013033 19990121
- 主分类号: C12P4100
- IPC分类号: C12P4100
摘要:
The present invention has for its object to provide a practical method for the purification and isolation on a commercial scale of said compound (1) or compound (2) in good yield and with high quality. The present invention provides a purification/isolation method of a (2S,3S)-1-halo-2-hydroxy-3-N-(tert-butoxycarbonyl)amino-4-phenylbutane (1) or a (2R,3S)-1-halo-2-hydroxy-3-N-(tert-butoxycarbonyl)amino-4-phenylbutane (2) which comprises, for the purpose of removing contaminant impurity from a mixture containing at least one of said compounds (1) and (2), causing the objective compound (1) or compound (2) to be crystallized in the presence of a solvent comprised of a hydrocarbon solvent and then collecting the obtained crystals.