发明授权
- 专利标题： Expression systems utilizing autolyzing fusion proteins and a novel reducing polypeptide
- 专利标题（中）： 使用自溶融合蛋白和新型还原多肽的表达系统
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申请号： US09842347申请日： 2001-04-25
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公开(公告)号： US06743611B2公开(公告)日： 2004-06-01
- 发明人: Tohru Takahashi , Nobufusa Serizawa , Ryuta Koishi , Ichiro Kawashima
- 申请人： Tohru Takahashi , Nobufusa Serizawa , Ryuta Koishi , Ichiro Kawashima
- 优先权： JP6/161053 19940713; JP6/218392 19940913; JP6/303809 19941207
- 主分类号： C12N902
- IPC分类号： C12N902
摘要：
The present invention provides expression systems for exogenous polypeptides wherein the polypeptide is expressed as a fusion protein together with clover yellow virus Nuclear Inclusion a (NIa), the NIa component serving to autolyze the fusion protein after expression. This system can be used to express a novel polypeptide which we have designated KM31-7 protein and which is capable of reducing dichloroindophenol and reduced glutathione. This polypeptide is useful in the treatment of disorders caused by oxidative stress.