发明授权
US06777421B2 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
有权
可用于治疗ORL-1受体介导的疾病的1,3,8-三氮杂螺[4.5]癸-4-酮衍生物
![1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders](/docs/US/2004-08-17/US06777421B2/abs.jpg.600x600.jpg)
- 专利标题： 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
- 专利标题（中）： 可用于治疗ORL-1受体介导的疾病的1,3,8-三氮杂螺[4.5]癸-4-酮衍生物
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申请号： US10117674申请日： 2002-04-05
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公开(公告)号： US06777421B2公开(公告)日： 2004-08-17
- 发明人: Alfonzo Jordan , Allen B. Reitz , Kevin Pan
- 申请人： Alfonzo Jordan , Allen B. Reitz , Kevin Pan
- 主分类号： A61K314353
- IPC分类号： A61K314353
![1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders](/abs-image/US/2004/08/17/US06777421B2/abs.jpg.150x150.jpg)
摘要：
The present invention is directed to novel 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, substance abuse, neuropathic pain, acute pain, migraine, asthma, cough and for improved cognition.
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