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1.发明授权公开(公告)号：US08501791B2
公开(公告)日：2013-08-06
申请号：US12835220
申请日：2010-07-13
申请人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
发明人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
IPC分类号： A61K31/433 , C07D285/08
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D333/16 , C07D417/12 , C07F9/4018
摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
摘要翻译： 本发明涉及可用作黑皮质素受体的激动剂或拮抗剂的新颖的1,2,4-噻二唑-2-基衍生物。 更具体地，本发明的化合物可用于治疗代谢，CNS和皮肤病学障碍，例如肥胖症，口服葡萄糖耐量降低，血糖水平升高，II型糖尿病，X综合征，糖尿病性视网膜病变，脊髓损伤，神经 伤口，急性神经退行性疾病，慢性神经退行性疾病，性欲症，男性勃起功能障碍，干眼症，痤疮，干性皮肤，老年皮肤，脂溢性皮炎，酒渣鼻，过度耳垢，睑板腺疾病，假性结石炎，酵母菌感染，头皮屑， 眼红斑痤疮和外分泌腺疾病。
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2.发明申请0NOVEL, 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS 失效0号，1,2,4-噻二唑衍生物作为米考康宁受体调节剂公开(公告)号：US20100280079A1
公开(公告)日：2010-11-04
申请号：US12835220
申请日：2010-07-13
申请人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
发明人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
IPC分类号： A61K31/433 , A61K31/4439 , A61P25/00 , A61P17/00 , A61P3/00 , A61P15/00
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D333/16 , C07D417/12 , C07F9/4018
摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
摘要翻译： 本发明涉及可用作黑皮质素受体的激动剂或拮抗剂的新颖的1,2,4-噻二唑-2-基衍生物。 更具体地，本发明的化合物可用于治疗代谢，CNS和皮肤病学障碍，例如肥胖症，口服葡萄糖耐量降低，血糖水平升高，II型糖尿病，X综合征，糖尿病性视网膜病变，脊髓损伤，神经 伤口，急性神经退行性疾病，慢性神经退行性疾病，性欲症，男性勃起功能障碍，干眼症，痤疮，干性皮肤，老年皮肤，脂溢性皮炎，酒渣鼻，过度耳垢，睑板腺疾病，假性结石炎，酵母菌感染，头皮屑， 眼红斑痤疮和外分泌腺疾病。
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公开(公告)号：US08934261B2
公开(公告)日：2015-01-13
申请号：US12489429
申请日：2009-06-23
CPC分类号： H01R13/111 , H01R9/091 , H01R12/57 , H01R12/58 , H01R13/6675 , H05K1/141 , H05K1/145 , H05K3/366 , H05K2201/048 , H05K2201/09181 , H05K2201/10189 , Y10T29/49002 , Y10T29/49117
摘要： High density electronic device assemblies and techniques for forming high density electronic device assemblies are disclosed. These assemblies and techniques can be used to form compact electronic devices. In one embodiment, substrate arrangements that include a multiple-part substrate can be used to form a high density electronic device assembly. In another embodiment, one or more clips can be used in a high density electronic device assembly to provide mechanical and electrical interconnection between electrical structures that are to be removably coupled together as parts of the high density electronic device assembly. In still another embodiment, a removable cap (and a method for forming the removable cap) can be used for an electronic device housing.
摘要翻译： 公开了用于形成高密度电子器件组件的高密度电子器件组件和技术。 这些组件和技术可用于形成紧凑的电子设备。 在一个实施例中，包括多部分衬底的衬底布置可用于形成高密度电子器件组件。 在另一个实施例中，一个或多个夹子可用于高密度电子器件组件中，以提供电气结构之间的机械和电气互连，电气结构可以作为高密度电子器件组件的部件可拆卸地耦合在一起。 在另一个实施例中，可拆卸盖（以及用于形成可拆卸盖的方法）可用于电子设备外壳。
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4.发明授权公开(公告)号：US07786311B2
公开(公告)日：2010-08-31
申请号：US12221900
申请日：2008-08-05
申请人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
发明人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
IPC分类号： C07D285/08
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D333/16 , C07D417/12 , C07F9/4018
摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
摘要翻译： 本发明涉及可用作黑皮质素受体的激动剂或拮抗剂的新颖的1,2,4-噻二唑-2-基衍生物。 更具体地，本发明的化合物可用于治疗代谢，CNS和皮肤病学障碍，例如肥胖症，口服葡萄糖耐量降低，血糖水平升高，II型糖尿病，X综合征，糖尿病性视网膜病变，脊髓损伤，神经 伤口，急性神经退行性疾病，慢性神经退行性疾病，性欲症，男性勃起功能障碍，干眼症，痤疮，干性皮肤，老年皮肤，脂溢性皮炎，酒渣鼻，过度耳垢，睑板腺疾病，假性结石炎，酵母菌感染，头皮屑， 眼红斑痤疮和外分泌腺疾病。
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5.发明申请Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators 有权新型1,2,4-噻二唑衍生物作为黑皮质素受体调节剂公开(公告)号：US20090203751A1
公开(公告)日：2009-08-13
申请号：US12221900
申请日：2008-08-05
申请人： Magdalena Eisinger Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
发明人： Magdalena Eisinger Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
IPC分类号： A61K31/433 , A61P3/00 , A61P17/00 , C07C335/04
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D333/16 , C07D417/12 , C07F9/4018
摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
摘要翻译： 本发明涉及可用作黑皮质素受体的激动剂或拮抗剂的新颖的1,2,4-噻二唑-2-基衍生物。 更具体地，本发明的化合物可用于治疗代谢，CNS和皮肤病学障碍，例如肥胖症，口服葡萄糖耐量降低，血糖水平升高，II型糖尿病，X综合征，糖尿病性视网膜病变，脊髓损伤，神经 伤口，急性神经退行性疾病，慢性神经退行性疾病，性欲症，男性勃起功能障碍，干眼症，痤疮，干性皮肤，老年皮肤，脂溢性皮炎，酒渣鼻，过度耳垢，睑板腺疾病，假性结石炎，酵母菌感染，头皮屑， 眼红斑痤疮和外分泌腺疾病。
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6.发明申请1,2,8-Triazaspiro{decan-4-one derivatives useful for the treatment of orl-1receptor mediated disorders 有权1,2,8-三氮杂螺[可用于治疗orl-1受体介导的病症的癸烷-4-酮衍生物公开(公告)号：US20050004154A1
公开(公告)日：2005-01-06
申请号：US10909858
申请日：2004-08-02
申请人： Alfonzo Jordan , Allen Reitz , Kevin Pan
发明人： Alfonzo Jordan , Allen Reitz , Kevin Pan
IPC分类号： A61K31/438 , A61P11/06 , A61P11/14 , A61P25/00 , A61P25/06 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P43/00 , C07D471/10 , A61K31/4747
CPC分类号： C07D471/10
摘要： The present invention is directed to novel 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, substance abuse, neuropathic pain, acute pain, migraine, asthma, cough and for improved cognition.
摘要翻译： 本发明涉及通式的新的1,3,8-三氮杂螺[4.5]癸-4-酮衍生物，其中所有变量如本文所定义，可用于治疗ORL-1 G介导的病症和病症 蛋白偶联受体。 更具体地，本发明的化合物可用于治疗诸如焦虑，抑郁，药物滥用，神经性疼痛，急性疼痛，偏头痛，哮喘，咳嗽和改善认知的病症和病症。
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公开(公告)号：US06509369B2
公开(公告)日：2003-01-21
申请号：US10041423
申请日：2002-01-08
申请人： Malcolm K. Scott , Pauline J. Sanfilippo , Louis J. Fitzpatrick, III , Richard Cordova , Kevin Pan , Joseph Meschino
发明人： Malcolm K. Scott , Pauline J. Sanfilippo , Louis J. Fitzpatrick, III , Richard Cordova , Kevin Pan , Joseph Meschino
IPC分类号： A61K31381
CPC分类号： C07C311/13 , C07C233/05 , C07C233/11 , C07C233/13 , C07C271/44 , C07C311/16 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2603/18 , C07C2603/32 , C07D209/18 , C07D209/42 , C07D213/56 , C07D333/24 , C07D333/38 , C07D333/60 , C07D333/70
摘要： This invention relates to anti-inflammatory compounds, methods of making such compounds and methods of using such compounds having the following structure:
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公开(公告)号：US20120155041A1
公开(公告)日：2012-06-21
申请号：US13407625
申请日：2012-02-28
CPC分类号： H01R13/111 , H01R12/00 , H01R12/57 , H01R12/58 , H01R13/6675 , H05K1/141 , H05K1/145 , H05K3/366 , H05K2201/048 , H05K2201/09181 , H05K2201/10189 , Y10T29/49002 , Y10T29/49117
摘要： High density electronic device assemblies and techniques for forming high density electronic device assemblies are disclosed. These assemblies and techniques can be used to form compact electronic devices, such as portable power adapters. In one embodiment, substrate arrangements that include a multiple-part substrate can be used to form a high density electronic device assembly. In another embodiment, one or more clips can be used in a high density electronic device assembly to provide mechanical and electrical interconnection between electrical structures that are to be removably coupled together as parts of the high density electronic device assembly. In still another embodiment, a removable cap (and a method for forming the removable cap) can be used for an electronic device housing.
摘要翻译： 公开了用于形成高密度电子器件组件的高密度电子器件组件和技术。 这些组件和技术可用于形成诸如便携式电源适配器之类的紧凑型电子设备。 在一个实施例中，包括多部分衬底的衬底布置可用于形成高密度电子器件组件。 在另一个实施例中，一个或多个夹子可用于高密度电子器件组件中，以提供电气结构之间的机械和电气互连，电气结构可以作为高密度电子器件组件的部件可拆卸地耦合在一起。 在另一个实施例中，可拆卸盖（以及用于形成可拆卸盖的方法）可用于电子设备外壳。
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9.发明授权公开(公告)号：US07375123B2
公开(公告)日：2008-05-20
申请号：US11344772
申请日：2006-02-01
申请人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
发明人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
IPC分类号： A61K31/433 , C07D285/08
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D417/12
摘要： The present invention is directed to novel 1,2,4-thiadiazole derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
摘要翻译： 本发明涉及可用作黑皮质素受体的激动剂或拮抗剂的新颖的1,2,4-噻二唑衍生物。 更具体地，本发明的化合物可用于治疗代谢，CNS和皮肤病学障碍，例如肥胖症，口服葡萄糖耐量降低，血糖水平升高，II型糖尿病，X综合征，糖尿病性视网膜病变，脊髓损伤，神经 伤口，急性神经退行性疾病，慢性神经退行性疾病，性欲症，男性勃起功能障碍，干眼症，痤疮，干性皮肤，老年皮肤，脂溢性皮炎，酒渣鼻，过度耳垢，睑板腺疾病，假性结石炎，酵母菌感染，头皮屑， 眼红斑痤疮和外分泌腺疾病。
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公开(公告)号：US07141674B2
公开(公告)日：2006-11-28
申请号：US10690341
申请日：2003-10-21
申请人： Malcolm K. Scott , Pauline J. Sanfilippo , Louis J. Fitzpatrick, III , Richard Cordova , Kevin Pan , Joseph Meschino
发明人： Malcolm K. Scott , Pauline J. Sanfilippo , Louis J. Fitzpatrick, III , Richard Cordova , Kevin Pan , Joseph Meschino
IPC分类号： C07D211/72 , C07D209/02 , C07D333/56
CPC分类号： C07C311/13 , C07C233/05 , C07C233/11 , C07C233/13 , C07C271/44 , C07C311/16 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2603/18 , C07C2603/32 , C07D209/18 , C07D209/42 , C07D213/56 , C07D333/24 , C07D333/38 , C07D333/60 , C07D333/70
摘要： This invention relates to anti-inflammatory compounds, methods of making such compounds and methods of using such compounds having the following structure:
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