发明授权
- 专利标题: Chimeric peptide immunogens
- 专利标题(中): 嵌合肽免疫原
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申请号: US09848834申请日: 2001-05-04
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公开(公告)号: US06783761B2公开(公告)日: 2004-08-31
- 发明人: Stephen Grimes , Dov Michaeli , Vernon C. Stevens
- 申请人: Stephen Grimes , Dov Michaeli , Vernon C. Stevens
- 主分类号: A61K3900
- IPC分类号: A61K3900
摘要:
Chimeric peptide epitopes can serve as effective immunogens against hormones and other small peptides or proteins. Thus, immunogenic peptides are selected from promiscuous Th epitopes and synthesized together with self antigenic peptide sequences fused with or without end to end spacer peptide interconnections. A peptide sequence which may be of the gonadotropin releasing hormone is linked with an immunogenic peptide sequence selected from a promiscuous Th-epitope of measles virus protein F, tetanus toxoid, or malaria protein CSP. Compositions of the chimeric immunogen are found effective in eliciting high and specific anti-GnRH antibody titers.
公开/授权文献
- US20020076416A1 Chimeric peptide immunogens 公开/授权日:2002-06-20