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51 条记录 (耗时 0.027 秒)

    Reusable air filter
    1.
    发明授权
    Reusable air filter 有权

    公开(公告)号：US10898843B2

    公开(公告)日：2021-01-26

    申请号：US15878605

    申请日：2018-01-24

    申请人： Samuel Stephen Grimes

    发明人： Samuel Stephen Grimes

    IPC分类号： B01D53/22 ,  B01D46/42 ,  B01D46/00 ,  B01D46/12 ,  B01D39/08 ,  B01D39/12

    摘要： An air filtration system is provided. The air filtration system embodies filtration material supported by a frame, wherein the air filtration system provides two framed filtration materials sandwiching a fabric filter. Such framework may be removably engaged through magnetic forces. The filtration material may hold and/or carry electrostatic forces and/or magnetostatic forces induced through a current from an electrical power source and/or magnetic forces of the magnetics.

    Gastrin hormone immunoassays
    3.
    发明授权
    Gastrin hormone immunoassays 有权

    公开(公告)号：US07235376B2

    公开(公告)日：2007-06-26

    申请号：US10813336

    申请日：2004-03-29

    申请人： Stephen Grimes ,  John Little ,  Lorraine McLoughlin

    发明人： Stephen Grimes ,  John Little ,  Lorraine McLoughlin

    IPC分类号： G01N33/53 ,  G01N33/537 ,  G01N33/543 ,  C07K16/00

    CPC分类号： G01N33/6893 ,  G01N33/74 ,  G01N2333/595

    摘要： The invention provides assay methods for the detection and quantitation of gastrin hormones, including total and free gastrin hormone in a sample. ELISA-type heterogeneous phase assays suitable for use with biological fluid samples such as blood, plasma or other bodily fluids of a mammal, particularly a human subject are provided. The method provides a precise assay for the amounts of free and total G17 and G34 in biological fluid samples, as well as the amounts of free and total Gly-extended G17, and Gly-extended G34. Also provided are methods of determining suitable treatment for patient suffering from a gastrin hormone-mediated disease or condition employing gastrin hormone immunoassays.

    Monoclonal antibodies to gastrin hormone
    7.
    发明申请
    Monoclonal antibodies to gastrin hormone 审中-公开
    胃泌素激素单克隆抗体

    公开(公告)号：US20060020119A1

    公开(公告)日：2006-01-26

    申请号：US11093724

    申请日：2005-03-29

    申请人： Stephen Grimes ,  Ronald Makishima

    发明人： Stephen Grimes ,  Ronald Makishima

    IPC分类号： C07K16/26 ,  G01N33/53 ,  C12Q1/68

    CPC分类号： C07K16/26 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/73 ,  G01N33/577 ,  G01N33/74 ,  G01N2333/595

    摘要： The present invention provides monoclonal antibodies (MAbs) selective for the N-termini and C-termini of the gastrin hormone forms, gastrin-17 (G17), glycine-extended gastrin-17 (G17-Gly), gastrin-34 (G34) and glycine-extended gastrin-34 (G34-Gly); and the hybridomas that produce these MAbs. Also provided are panels of MAbs useful for the detection and quantitation of gastrin-17 (G17), glycine-extended gastrin-17 (G17-Gly), gastrin-34 (G34) and glycine-extended gastrin-34 (G34-Gly). These assays are useful for monitoring a gastrin-mediated disease or condition, or for monitoring the progress of a course of therapy. The invention further provides solid phase assays including immunohistochemical (IHC) and immunofluorescence (IF) assays suitable for detection and visualization of gastrin species in solid samples, such as biopsy samples or tissue slices. Pharmaceutical compositions of the MAbs of the invention are also provided, along with methods of diagnosis, prevention and treatment of gastrin-mediated diseases or conditions. Methods of evaluating a gastrin hormone-blocking treatment are described. The course of a gastrin-mediated disease or condition may be monitored in a patient by means of assay methods provided.

    摘要翻译： 本发明提供对胃泌素激素形式的N-末端和C-末端选择性的单克隆抗体（MAb），胃泌素-17（G17），甘氨酸延长胃泌素-17（G17-Gly），胃泌素-34（G34） 和甘氨酸延长胃泌素-34（G34-Gly）; 和产生这些MAb的杂交瘤。 还提供了可用于检测和定量胃泌素-17（G17），甘氨酸延长胃泌素-17（G17-Gly），胃泌素-34（G34）和甘氨酸延长胃泌素-34（G34-Gly） 。 这些测定法可用于监测胃泌素介导的疾病或病症，或用于监测治疗过程的进展。 本发明进一步提供固相测定法，包括免疫组织化学（IHC）和免疫荧光（IF）测定法，其适于检测和可视化固体样品例如活检样本或组织切片中的胃泌素种类。 还提供本发明的MAb的药物组合物以及胃泌素介导的疾病或病症的诊断，预防和治疗的方法。 描述了评估胃泌素激素阻断治疗的方法。 胃泌素介导的疾病或病症的过程可以通过提供的测定方法在患者体内监测。

    Prevention and treatment of hypergastrinemia
    8.
    发明申请
    Prevention and treatment of hypergastrinemia 审中-公开
    预防和治疗高胃泌素血症

    公开(公告)号：US20050187152A1

    公开(公告)日：2005-08-25

    申请号：US10829137

    申请日：2004-04-21

    申请人： Philip Gevas ,  Stephen Grimes ,  Stephen Karr ,  Dov Michaeli ,  Susan Watson

    发明人： Philip Gevas ,  Stephen Grimes ,  Stephen Karr ,  Dov Michaeli ,  Susan Watson

    IPC分类号： A61K39/385 ,  A61K38/00 ,  A61K38/22 ,  A61K47/48 ,  A61P7/00 ,  A61P37/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/595 ,  C07K16/26 ,  C07K16/40 ,  A61K38/17 ,  A61K31/4172 ,  A61K31/4439

    CPC分类号： C07K16/26 ,  A61K38/2207 ,  A61K47/643 ,  A61K2039/505 ,  C07K14/595 ,  C07K2317/34

    摘要： Serum-associated hypergastrinemia is treated by administration of gastrin active or passive immunization. An anti-gastrin immunogenic composition containing a gastrin G17 or G34 peptide fragment which is amino acid spacer-linked to an immunogenic carrier, is administered so as to effectively neutralize the circulating gastrin hormone, and moreover, inhibit autocrine activity by progastrin such as Gly-extended G17, and amidated G17, in patients with pernicious anemia. Moreover, the method includes administration of a therapeutically effective amount of anti-G17 or anti-G34 antibodies which may be in humanized form. Finally, the method provides ameliorating treatment of hypergastrinemic effects of proton pump inhibitors or H2 histamine receptor blocking agents or antagonists, in addition to treatment of hypergastrinemia caused by diseases such as pernicious anemia.

    摘要翻译： 通过施用胃泌素活性或被动免疫来治疗血清相关性高胃泌素血症。 给予含有与免疫原性载体间隔连接的氨基酸的胃泌素G17或G34肽片段的抗胃泌素免疫原性组合物，以有效中和循环的胃泌素激素，此外，抑制前胃泌素如Gly- 延长G17，并与G17阴性，患有恶性贫血患者。 此外，该方法包括施用治疗有效量的可以以人源化形式存在的抗G17或抗G34抗体。 最后，除了治疗由诸如恶性贫血等疾病引起的胃泌素血症外，该方法还提供改善质子泵抑制剂或H 2 H 2组胺受体阻断剂或拮抗剂的高胃肠道作用的改善。

    Liposomal vaccine
    9.
    发明申请
    Liposomal vaccine 审中-公开
    脂质体疫苗

    公开(公告)号：US20050169979A1

    公开(公告)日：2005-08-04

    申请号：US11036690

    申请日：2005-01-14

    申请人： Dov Michaeli ,  Stephen Grimes ,  Yechezkel Barenholz ,  Simcha Even-Chen ,  Susan Hagan

    发明人： Dov Michaeli ,  Stephen Grimes ,  Yechezkel Barenholz ,  Simcha Even-Chen ,  Susan Hagan

    IPC分类号： A61K9/127 ,  A61K39/00 ,  C12N5/02 ,  C12N15/88

    CPC分类号： A61K9/127 ,  A61K38/09 ,  A61K38/2207 ,  A61K38/27

    摘要： The invention provides liposomal vehicles for encapsulating relatively high levels of immunogenic protein substances including immunogens directed against hormones and hormone receptors, such as gastrin and gonadotropin releasing hormone and their receptors. The liposome encapsulating large amounts of immunogens can be injected parenterally to induce effective immune responses without exhibiting significant adverse tissue reactogenicity. Methods for production of the liposomal vaccines and methods of their administration for treatment of diseases and conditions associated with the cognate hormones are also provided.

    摘要翻译： 本发明提供用于包封相对高水平的免疫原性蛋白质物质的脂质体载体，包括针对激素和激素受体的免疫原，例如胃泌素和促性腺激素释放激素及其受体。 包封大量免疫原的脂质体可以肠胃外注射以诱导有效的免疫应答，而不显示显着的不利组织反应原性。 还提供了用于生产脂质体疫苗的方法及其用于治疗与同类激素相关的疾病和病症的施用方法。