发明授权
- 专利标题: Method for producing 2-chloro-5-chloromethyl-1,3-thiazole
- 专利标题(中): 2-氯-5-氯甲基-1,3-噻唑的制备方法
-
申请号: US10296488申请日: 2003-03-27
-
公开(公告)号: US06787654B2公开(公告)日: 2004-09-07
- 发明人: Sylvia Krich , Christian Burger , Johann Altreiter , Birgit Zwölfer
- 申请人: Sylvia Krich , Christian Burger , Johann Altreiter , Birgit Zwölfer
- 优先权: ATA895/2000 20000523
- 主分类号: C07D27732
- IPC分类号: C07D27732
摘要:
A process for the preparation of 2-chloro-5-chloromethyl-1,3-thiazole, in which allyl isothiocyanate of formula CH2═CH—CH2—NCS is reacted at from −40° C. to +30° C., in a solvent that is inert under the reaction conditions, with from 1 to 2 mol of a chlorinating agent per mol of allyl isothiocyanate; to the reaction mixture so obtained there is added, at a reaction temperature of from 0° C. to the boiling temperature of the solvent used, from 1 to 5 mol of oxidising agent per mol of allyl isothiocyanate, and then 2-chloro-5-chloromethyl-1,3-thiazole is isolated from the reaction mixture and is optionally converted by crystallisation into high-purity 2-chloro-5-chloromethyl-1,3-thiazole.
公开/授权文献
信息查询