公开(公告)号：US06787654B2

公开(公告)日：2004-09-07

申请号：US10296488

申请日：2003-03-27

申请人： Sylvia Krich ,  Christian Burger ,  Johann Altreiter ,  Birgit Zwölfer

发明人： Sylvia Krich ,  Christian Burger ,  Johann Altreiter ,  Birgit Zwölfer

IPC分类号： C07D27732

CPC分类号： C07D277/32

摘要： A process for the preparation of 2-chloro-5-chloromethyl-1,3-thiazole, in which allyl isothiocyanate of formula CH2═CH—CH2—NCS is reacted at from −40° C. to +30° C., in a solvent that is inert under the reaction conditions, with from 1 to 2 mol of a chlorinating agent per mol of allyl isothiocyanate; to the reaction mixture so obtained there is added, at a reaction temperature of from 0° C. to the boiling temperature of the solvent used, from 1 to 5 mol of oxidising agent per mol of allyl isothiocyanate, and then 2-chloro-5-chloromethyl-1,3-thiazole is isolated from the reaction mixture and is optionally converted by crystallisation into high-purity 2-chloro-5-chloromethyl-1,3-thiazole.

摘要翻译： 制备2-氯-5-氯甲基-1,3-噻唑的方法，其中式CH 2 = CH-CH 2 -NCS的异硫氰酸烯丙酯在-40℃至+ 30℃下反应，在 在反应条件下为惰性的溶剂，每摩尔异硫氰酸烯丙酯为1至2摩尔氯化剂; 向如此获得的反应混合物中，在0℃至所用溶剂的沸点的反应温度下，每摩尔异硫氰酸烯丙基酯加入1至5摩尔氧化剂，然后加入2-氯-5 - 氯甲基-1,3-噻唑从反应混合物中分离出来，任选地通过结晶转化为高纯度2-氯-5-氯甲基-1,3-噻唑。