发明授权
- 专利标题： Process for lactonization to produce simvastatin
- 专利标题（中）： 内酯化生产辛伐他汀的方法
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申请号： US10440537申请日： 2003-05-19
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公开(公告)号： US06797831B2公开(公告)日： 2004-09-28
- 发明人: Ramesh Dandala , Sonny Sebastian , Sanapureddy Jagan Mohan Reddy , Meenakshisunderam Sivakumaran
- 申请人： Ramesh Dandala , Sonny Sebastian , Sanapureddy Jagan Mohan Reddy , Meenakshisunderam Sivakumaran
- 主分类号： C07D30930
- IPC分类号： C07D30930
摘要：
There is disclosed a process for the manufacture of simvastatin of Formula I which comprises heating a compound, namely acid or ammonium salt of compound of Formula II, where Z is H or NH4 in an organic solvent at a temperature of 130-140° C.
公开/授权文献
- US20040019225A1 Process for lactonization to produce simvastatin 公开/授权日：2004-01-29
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