Alpha amino acid derivatives—inhibitors of leukocyte adhesion mediated by VLA-4

发明授权

US06803370B2 Alpha amino acid derivatives—inhibitors of leukocyte adhesion mediated by VLA-4 失效

标题翻译： α氨基酸衍生物 - 由VLA-4介导的白细胞粘附抑制剂

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专利标题： Alpha amino acid derivatives—inhibitors of leukocyte adhesion mediated by VLA-4
专利标题（中）： α氨基酸衍生物 - 由VLA-4介导的白细胞粘附抑制剂
申请号： US09910702

申请日： 2001-07-20
公开(公告)号： US06803370B2

公开(公告)日： 2004-10-12
发明人: Andrei W. Konradi , Michael A. Pleiss , Eugene D. Thorsett , Susan Ashwell , Gregory S. Welmaker , Anthony Kreft , Dimitrios Sarantakis , Darren B. Dressen , Francine S. Grant , Christopher Semko , Ying-Zi Xu
申请人： Andrei W. Konradi , Michael A. Pleiss , Eugene D. Thorsett , Susan Ashwell , Gregory S. Welmaker , Anthony Kreft , Dimitrios Sarantakis , Darren B. Dressen , Francine S. Grant , Christopher Semko , Ying-Zi Xu
主分类号： A61K31519
IPC分类号： A61K31519

Alpha amino acid derivatives—inhibitors of leukocyte adhesion mediated by VLA-4

摘要：

Disclosed are certain alpha amino acid compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

摘要（中）：

公开了结合VLA-4的某些α氨基酸化合物。这些化合物中的某些也抑制白细胞粘附，特别是由VLA-4介导的白细胞粘附。这样的化合物可用于治疗哺乳动物患者，例如人类例如哮喘，阿尔茨海默氏病，动脉粥样硬化，艾滋病痴呆，糖尿病，炎性肠病，类风湿性关节炎，组织移植，肿瘤转移和心肌缺血等炎性疾病。化合物也可以用于治疗炎性脑疾病如多发性硬化症。

公开/授权文献

US20020052470A1 Alpha amino acid derivatives--inhibitors of leukocyte adhesion mediated by VLA-4 公开/授权日：2002-05-02

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