A system for communication with addressable electronically-controllable appliances using a generalized pointing device is provided. The system includes a pointing device that can communicate with dissimilar types of target appliances from a position remote from those appliances and an appliance interface that makes the target appliances compatible with the pointing device. Use of the system is believed to allow the convenience associated with use of a computer's graphical user interface (GUI) to be realized in communication with physical objects, i.e. the target appliances. In an embodiment for one-way communication from a pointing device to a target appliance, the pointing device may comprise an actuator, an input-output interface, and a transmitter. In an embodiment configured for two-way communication between the pointing device and an appliance, the pointing device may further include a receiver. The appliance interface may include a receiver, an input/output interface, and a driver to convert received pointer command signals to corresponding functions of the appliance. In an embodiment configured for two-way communication, the appliance interface may further include a transmitter. The system may be configured for transmission using optical signals, radio-frequency signals, or both.