Invention Grant
US06818446B2 Compositions and methods for the analysis of mucin gene expression and identification of drugs having the ability to inhibit mucin gene expression
有权
用于分析粘蛋白基因表达和鉴定具有抑制粘蛋白基因表达能力的药物的组合物和方法
- Patent Title: Compositions and methods for the analysis of mucin gene expression and identification of drugs having the ability to inhibit mucin gene expression
- Patent Title (中): 用于分析粘蛋白基因表达和鉴定具有抑制粘蛋白基因表达能力的药物的组合物和方法
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Application No.: US09990613Application Date: 2001-11-21
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Publication No.: US06818446B2Publication Date: 2004-11-16
- Inventor: Reen Wu , Yin Chen
- Applicant: Reen Wu , Yin Chen
- Main IPC: C12N1574
- IPC: C12N1574
Abstract:
The invention relates to compositions and methods for the assessment of mucin gene expression. The invention also relates to compositions and methods for the identification of compounds useful in the treatment of various disorders caused by mucin overproduction. The invention provides novel MUC5B promoter sequences and reporter constructs comprising these MUC5B promoter sequences. The invention further provides methods for drug screening to identify compounds have the ability to inhibit MUC5B gene expression. Compounds having the ability to inhibit MUC5B gene expression find use in the treatment of diseases characterized by mucin hyperproduction.
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