A non-volatile semiconductor memory device having a memory cell array region in which a plurality of memory cells, each having first and second MONOS memory cells controlled by a word gate and control gates, are arranged in first and second directions. The memory cell array region has a plurality of sector regions divided in the second direction. Each of a plurality of control gate drivers is capable of setting a potential of first and second control gates in the corresponding sector region independently of other sector regions. A plurality of switching elements which select connection/disconnection are formed at connections between a plurality of main bit lines and a plurality of sub bit lines.