发明授权
- 专利标题: Urocortin proteins and uses thereof
- 专利标题(中): 尿皮质蛋白及其用途
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申请号: US09919473申请日: 2001-07-31
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公开(公告)号: US06838274B2公开(公告)日: 2005-01-04
- 发明人: Wylie W. Vale, Jr. , Teresa M. Reyes , Paul E. Sawchenko , Jean E. Rivier , Kathy A. Lewis , John B. Hogenesch , Joan M. Vaughan , Marilyn H. Perrin
- 申请人: Wylie W. Vale, Jr. , Teresa M. Reyes , Paul E. Sawchenko , Jean E. Rivier , Kathy A. Lewis , John B. Hogenesch , Joan M. Vaughan , Marilyn H. Perrin
- 申请人地址: US NV Carson City
- 专利权人: Research Development Foundation
- 当前专利权人: Research Development Foundation
- 当前专利权人地址: US NV Carson City
- 代理机构: Seed IP Law Group PLLC
- 主分类号: C12N15/09
- IPC分类号: C12N15/09 ; A61K38/00 ; A61K38/22 ; A61K39/00 ; A61P3/00 ; A61P5/06 ; A61P9/04 ; A61P9/10 ; A61P25/18 ; A61P25/22 ; A61P25/24 ; A61P25/26 ; A61P25/28 ; A61P29/00 ; C07K14/435 ; C07K14/52 ; C07K14/575 ; C07K16/24 ; C12N1/21 ; C12N5/10 ; C12N15/12 ; C12N15/16 ; C12P21/08 ; C12R1/19 ; C12N15/63
摘要:
A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Both human URP and mouse Ucn II are structurally related to the other known mammalian family members, CRF and urocortin (Ucn). These peptides are involved in the regulation of the hypothalamic-pituituary-adrenal axis under basal and stress conditions, suggesting a similar role for URP and Ucn II. Synthesized Ucn-II and URP peptide binds with higher affinity to CRF-R2 than to CRF-R1 Ucn II and human URP appear to be involved in the regulation of body temperature and appetite and may play a role in other stress related phenomenon. These findings identify Ucn II and human URP as a new members of the CRF family of neuropeptides, which are expressed centrally and bind to CRF-R2.
公开/授权文献
- US20020127221A1 Urocortin proteins and uses thereof 公开/授权日:2002-09-12
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