发明授权
US06849463B2 Microfabricated devices for the storage and selective exposure of chemicals and devices
有权
用于化学品和设备的储存和选择性暴露的微型装置
- 专利标题: Microfabricated devices for the storage and selective exposure of chemicals and devices
- 专利标题(中): 用于化学品和设备的储存和选择性暴露的微型装置
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申请号: US10324556申请日: 2002-12-19
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公开(公告)号: US06849463B2公开(公告)日: 2005-02-01
- 发明人: John T. Santini, Jr. , Norman F. Sheppard, Jr. , Chung Chang Young , Robert S. Langer
- 申请人: John T. Santini, Jr. , Norman F. Sheppard, Jr. , Chung Chang Young , Robert S. Langer
- 申请人地址: US MA Bedford
- 专利权人: MicroCHIPS, Inc.
- 当前专利权人: MicroCHIPS, Inc.
- 当前专利权人地址: US MA Bedford
- 代理机构: Sutherland Asbill & Brennan LLP
- 主分类号: G01N21/64
- IPC分类号: G01N21/64 ; A61K9/00 ; A61K38/28 ; A61P3/10 ; B01J19/00 ; B01L3/00 ; B01L99/00 ; B81B1/00 ; C40B60/14 ; G01N21/27 ; G01N21/41 ; G01N27/12 ; G01N27/28 ; G01N27/327 ; G01N27/416 ; G01N33/66 ; G01N35/00 ; G01N33/543
摘要:
Microchip devices and methods of use are provided for the controlled exposure of a secondary device. In one embodiment, the microchip device include a substrate, a plurality of reservoirs in the substrate, a secondary device in one or more of the reservoirs, at least one barrier layer covering each of the reservoirs to isolate the secondary device from an environmental component outside the reservoirs, wherein the barrier layer is impermeable to the environmental component, and a microprocessor-controlled actuation means for rendering the barrier layer porous or permeable to the environmental component to expose the secondary device to said environmental component. The secondary device can comprise a sensor or sensing component (e.g., a biosensor). In other embodiments, microchip devices are provided for the controlled exposure of a reacting component, such as an enzyme. In still other embodiments, sensors are provided on the device outside of the reservoirs.