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发明授权
US06855847B2 Process for producing optically active amide from α β- unsaturated amide derivative in the presence of transition metal complex containing phosphine-phosphorane compound and transition metal 失效
在含有膦 - 正膦烷化合物和过渡金属的过渡金属络合物存在下，由α不饱和酰胺衍生物制备光学活性酰胺的方法

Process for producing optically active amide from α β- unsaturated amide derivative in the presence of transition metal complex containing phosphine-phosphorane compound and transition metal
摘要：
A novel process for producing an optically active amide excellent in chemical selectivity and enantioselectivity by asymmetric hydrogenation of an α,β-unsaturated amide and also allowing the reaction to proceed efficiently even when a trace amount of a catalyst is used relative to the substrate as compared with the amount in a conventional process. An optically active amide is produced by asymmetric hydrogenation of an α,β-unsaturated amide derivative in the presence of a transition metal complex containing a specific phosphine-phosphorane compound.
摘要（中）：

通过α，β-不饱和酰胺的不对称氢化制备具有优异的化学选择性和对映体选择性的光学活性酰胺的新方法，并且即使当相对于底物使用微量的催化剂时也允许反应有效地进行 以常规方法的量。 通过α，β-不饱和酰胺衍生物在含有特定膦 - 正膦烷化合物的过渡金属配合物存在下的不对称氢化制备光学活性酰胺。

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