发明授权
US06872840B1 Synthesis of 8-membered carbocyclic compound having diexomethylene groups
失效
具有阴离子亚甲基的8元碳环化合物的合成
- 专利标题: Synthesis of 8-membered carbocyclic compound having diexomethylene groups
- 专利标题(中): 具有阴离子亚甲基的8元碳环化合物的合成
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申请号: US10823708申请日: 2004-04-14
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公开(公告)号: US06872840B1公开(公告)日: 2005-03-29
- 发明人: Yong Seo Cho , Moon Ho Chang , Hun Yeong Koh , Ae Nim Pae , Hyun Jung Kang
- 申请人: Yong Seo Cho , Moon Ho Chang , Hun Yeong Koh , Ae Nim Pae , Hyun Jung Kang
- 申请人地址: KR
- 专利权人: Korea Institute of Science And Technology
- 当前专利权人: Korea Institute of Science And Technology
- 当前专利权人地址: KR
- 代理机构: Lowe Hauptman & Berner
- 优先权: KR10-2003-0064384 20030917
- 主分类号: A61K31/343
- IPC分类号: A61K31/343 ; C07B61/00 ; C07D493/08 ; C07D311/02 ; C07D311/78 ; C07D311/94
摘要:
The present invention relates to a synthesis of an 8-membered carbocyclic compound having diexomethylene groups, more particularly to a synthesis of an 8-membered carbocyclic compound having diexomethylene groups, a novel compound having the structure represented by the following Chemical Formula 1, from trimethylsilanylmethyl-allenol derivative by the intramolecular Prins cyclization using Lewis acid. The 8-membered carbocyclic compound is a useful intermediate for synthesis of other multicarbocyclic compounds. In Chemical Formula 1, R1 is a phenyl group, and R2 and R3 is a hydrogen atom, or R1, R2 and R3 may be connected with neighboring substituents to form a 5 to 10-membered aliphatic or aromatic ring.