- 专利标题： In vivo CTL elicitation by heat shock protein fusion proteins maps to a discrete domain and is CD4+ T cell-independent
-
申请号： US09761534申请日： 2001-01-16
-
公开(公告)号： US06875435B2公开(公告)日： 2005-04-05
- 发明人: Qian Huang , Joan F. L. Richmond , Bryan K. Cho , Deborah Palliser , Jianzhu Chen , Herman N. Eisen , Richard A. Young
- 申请人： Qian Huang , Joan F. L. Richmond , Bryan K. Cho , Deborah Palliser , Jianzhu Chen , Herman N. Eisen , Richard A. Young
- 申请人地址： US MA Cambridge US MA Cambridge
- 专利权人： Whitehead Institute for Biomedical Research,Massachusetts Institute of Technology
- 当前专利权人： Whitehead Institute for Biomedical Research,Massachusetts Institute of Technology
- 当前专利权人地址： US MA Cambridge US MA Cambridge
- 代理机构： Hamilton, Brook, Smith & Reynolds, P.C.
- 主分类号： A61K45/00
- IPC分类号： A61K45/00 ; A61K38/00 ; A61K39/00 ; A61K39/02 ; A61K39/04 ; A61K39/12 ; A61K39/21 ; A61K47/48 ; A61P31/04 ; A61P31/18 ; A61P35/00 ; A61P37/04 ; C07K14/35 ; A61K38/04 ; A61K39/385
摘要：
The present invention relates to a method of inducing a CD8+ CTL response to a molecule in an individual deficient in CD4+ T cells comprising administering to the individual an hsp or a portion of an ATP binding domain of an hsp joined to the molecule. In one embodiment, the present invention relates to a method of treating HIV in an individual deficient in CD4+ T cells comprising administering to the individual an hsp or a portion of an ATP binding domain of an hsp joined to the molecule. Also encompassed by the present invention is a method of inducing a CD4+ independent CTL response in an individual comprising administering to the individual a portion of an ATP binding domain of an hsp joined to the molecule. The present invention also relates to a method of inducing a CD8+ CTL response in an individual comprising administering to the individual a portion of an ATP binding domain of an hsp joined to the molecule. In addition, the present invention relates to a composition characterized by a portion of an ATP biding domain of an hsp joined to a molecule.
公开/授权文献
信息查询
