发明授权
US06881860B2 Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality
失效
提高血浆HDL胆固醇水平和提高HDL功能的化合物和方法
- 专利标题： Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality
- 专利标题（中）： 提高血浆HDL胆固醇水平和提高HDL功能的化合物和方法
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申请号： US09833407申请日： 2001-04-11
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公开(公告)号： US06881860B2公开(公告)日： 2005-04-19
- 发明人: Jayraz Luchoomun , Charles Q. Meng , Uday Saxena , James A. Sikorski
- 申请人： Jayraz Luchoomun , Charles Q. Meng , Uday Saxena , James A. Sikorski
- 申请人地址： US GA Alpharetta
- 专利权人： Atherogenics, Inc.
- 当前专利权人： Atherogenics, Inc.
- 当前专利权人地址： US GA Alpharetta
- 代理机构： King & Spalding, LLP
- 代理商 Sherry M. Knowles
- 主分类号： A61K31/7034
- IPC分类号： A61K31/7034 ; A61K31/10 ; A61K31/192 ; A61K31/198 ; A61K31/255 ; A61P3/06 ; C07C323/20 ; G01N33/92 ; C07C321/00
摘要：
It has been discovered that certain selected ethers of probucol, and their pharmaceutically acceptable salts or prodrugs, are useful for increasing circulating HDL cholesterol. These compounds may also improve HDL functionality by (a) increasing clearance of cholesteryl esters, (b) increasing HDL-particle affinity for hepatic cell surface receptors or (c) increasing the half life of apoAI-HDL.
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