发明授权
US06881868B2 Process for the preparation of (R)-2-alkyl-3-phenyl-1-propanols
失效
制备(R)-2-烷基-3-苯基-1-丙醇的方法
- 专利标题: Process for the preparation of (R)-2-alkyl-3-phenyl-1-propanols
- 专利标题(中): 制备(R)-2-烷基-3-苯基-1-丙醇的方法
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申请号: US10312992申请日: 2001-06-26
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公开(公告)号: US06881868B2公开(公告)日: 2005-04-19
- 发明人: Stefan Stutz , Peter Herold , Felix Spindler , Walter Weissensteiner , Thomas Sturm
- 申请人: Stefan Stutz , Peter Herold , Felix Spindler , Walter Weissensteiner , Thomas Sturm
- 申请人地址: CH Basel
- 专利权人: Speedel Pharma AG
- 当前专利权人: Speedel Pharma AG
- 当前专利权人地址: CH Basel
- 代理机构: Wenderoth, Lind & Ponack, L.L.P.
- 国际申请: PCTCH01/00398 WO 20010626
- 国际公布: WO0202487 WO 20020110
- 主分类号: C07C41/20
- IPC分类号: C07C41/20 ; C07B61/00 ; C07C29/147 ; C07C29/17 ; C07C43/23 ; C07C69/734 ; C07C69/736 ; C07C41/18
摘要:
Compounds of formula (I), wherein R1 and R2 are, independently of one another, H,C1-C6alkyl, C1-C6halogenalkyl, C1-C6alkoxyl, C1-C6alkoxy-C1-C6alkyl, or C1-C6alkoxy-C1-C6alkyloxy, and R3 is C1-C6alkyl, are obtainable in high yiedls by stereoselective addition of R3-substituted propionic acid esters to R1- and R2-substituted benzaldehydes of formula R—CHO to form corresponding 3-R-3-hydroxy-2-R3-propionic acid esters, conversion of the OH group to a leaving group, subsequent regioselective elimination to form 3-R-2-R3-propenic acid esters, and reduction to corresponding 3-R-2-R3-allyl alcohols and their enantioselective hydrogenation, wherein R is (a).
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