专利检索 ipc:"C07C69/736" 第 1 页

1.

发明授权
Prostacyclin compounds, compositions and methods of use thereof 有权

公开(公告)号：US11795135B2

公开(公告)日：2023-10-24

申请号：US17186658

申请日：2021-02-26

申请人： Insmed Incorporated

发明人： Vladimir Malinin , Walter Perkins , Franziska Leifer , Donna Konicek , Zhili Li , Adam Plaunt

IPC分类号： C07C69/734 , C07C69/712 , A61K47/60 , A61K47/54 , C07C69/736 , C07C69/753 , C07C235/22 , C07C235/20 , A61K31/165 , A61K31/216 , A61K31/225 , A61K47/06 , A61K9/00 , A61P9/12 , A61P11/00 , A61K9/10 , A61K9/14 , A61K9/51 , A61K47/14 , A61K47/24 , A61K47/28 , A61K47/34 , A61M15/00 , A61M16/14

CPC分类号： C07C69/734 , A61K9/0019 , A61K9/0043 , A61K9/0053 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/10 , A61K9/14 , A61K9/51 , A61K31/165 , A61K31/216 , A61K31/225 , A61K47/06 , A61K47/14 , A61K47/24 , A61K47/28 , A61K47/34 , A61K47/543 , A61K47/544 , A61K47/60 , A61M15/009 , A61M15/0085 , A61M16/14 , A61P9/12 , A61P11/00 , C07C69/712 , C07C69/736 , C07C69/753 , C07C235/20 , C07C235/22 , A61M2202/064 , C07C2601/18 , C07C2603/14

摘要： Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.

2.

发明公开
PREPARATION OF SUBSTITUTED ACRYLATE COMPOUND 审中-公开

公开(公告)号：US20230312455A1

公开(公告)日：2023-10-05

申请号：US18042901

申请日：2021-08-23

申请人： Hua Medicine (Shanghai) Ltd.

发明人： Jin She , Li Chen , Guanghua Lv , Xiangle Jin , Lizhen Xia , Jun Li

IPC分类号： C07C67/31 , C07C69/736

CPC分类号： C07C67/31 , C07C69/736

摘要： A method for preparing a substituted acrylate compound of general formula (I) is provided.

3.

发明授权
Modulators of lipoxygenase and cyclooxygenase enzyme activity 有权

公开(公告)号：US11760715B2

公开(公告)日：2023-09-19

申请号：US16081738

申请日：2017-03-03

申请人： Universite de Moncton

发明人： Mohamed Touaibia , Marc Edgar Surette

IPC分类号： C07C69/732 , C07C69/736 , C07C69/65 , C07C69/94 , C07D319/18 , C07C235/34 , C07C69/618 , C07C69/734

CPC分类号： C07C69/732 , C07C69/618 , C07C69/65 , C07C69/734 , C07C69/736 , C07C69/94 , C07C235/34 , C07D319/18

摘要： The present invention relates to modulators of lipoxygenase and/or cyclooxygenase enzyme. The present invention also provides compositions comprising such modulators, and methods therewith for treating lipoxygenase receptor mediated diseases.

4.

发明授权
Polymeric biomaterials derived from phenolic monomers and their medical uses 有权

公开(公告)号：US11649203B2

公开(公告)日：2023-05-16

申请号：US16984850

申请日：2020-08-04

申请人： Rutgers, The State University of New Jersey

发明人： Durgadas Bolikal , Joachim B. Kohn

IPC分类号： C07C69/732 , C08G64/10 , C07C69/734 , C07C233/51 , C07C69/84 , C08G64/38 , A61L31/18 , A61L31/14 , A61L31/16 , A61L31/06 , C08G64/06 , C08G64/12 , C07C69/40 , C07C233/47 , C07C69/736 , C07C69/36

CPC分类号： C07C69/732 , A61L31/06 , A61L31/148 , A61L31/16 , A61L31/18 , C07C69/36 , C07C69/40 , C07C69/734 , C07C69/736 , C07C69/84 , C07C233/47 , C07C233/51 , C08G64/06 , C08G64/10 , C08G64/12 , C08G64/38 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2300/604 , A61L31/06 , C08L69/00

摘要： Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula

These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.

5.

发明申请
RADIATION-SENSITIVE RESIN COMPOSITION, METHOD OF FORMING RESIST PATTERN, POLYMER, AND COMPOUND 有权

公开(公告)号：US20220299873A1

公开(公告)日：2022-09-22

申请号：US17829531

申请日：2022-06-01

申请人： JSR CORPORATION

发明人： Ryuichi NEMOTO , Ryotaro TANAKA , Taiichi FURUKAWA , Katsuaki NISHIKORI , Hiromitsu NAKASHIMA

IPC分类号： G03F7/039 , G03F7/038 , C07C69/734 , C07D307/00 , C07C69/736 , C07C69/96 , C08F220/28 , C08F220/38 , C08F220/36 , C08F212/14 , C08F220/30

摘要： A radiation-sensitive resin composition includes: a first polymer including a structural unit including an acid-labile group; a second polymer including a structural unit represented by formula (1); and a radiation-sensitive acid generator. In the formula (1), A represents an oxygen atom or a sulfur atom; a sum of m and n is 2 or 3, wherein m is 1 or 2, and n is 1 or 2; X represents a single bond or a divalent organic group having 1 to 20 carbon atoms; and R1 represents a monovalent organic group including a fluorine atom.

6.

发明申请
FUNGICIDAL COMPOUNDS 有权

公开(公告)号：US20220240504A1

公开(公告)日：2022-08-04

申请号：US17593662

申请日：2020-03-20

申请人： SYNGENTA CROP PROTECTION AG

发明人： Stefano RENDINE , Farhan BOUHAMDAN , Laura QUARANTA , Simon WILLIAMS , Matthias WEISS , Thomas James HOFFMAN

IPC分类号： A01N37/34 , C07C69/736 , A01N37/10 , A01P3/00 , A01N37/38 , C07C69/738 , C07C255/46 , C07C251/44

摘要： Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.

7.

发明申请
MIGRATION-RESISTANT PHOTOPOLYMERIZATION SENSITIZER 有权

公开(公告)号：US20220106254A1

公开(公告)日：2022-04-07

申请号：US17312274

申请日：2019-03-29

申请人： Kawasaki Kasei Chemicals Ltd.

发明人： Akihiko YAMADA , Hidehiko TANAKA , Shigeaki NUMATA

IPC分类号： C07C69/736 , C08F2/50

摘要： A photopolymerization sensitizer may not cause problems of dusting or coloring of a cured product due to bleeding of additives such as the photopolymerization sensitizer on the surface, e.g., by blooming at the time of photo-curing or during storage of the cured product, and which provides a practically sufficient photo-curing rate. A 9,10-bis(alkoxycarbonylalkyleneoxy)anthracene compound having ester groups, of formula (I): wherein A is a C1-20 alkylene group, optionally branched by an alkyl group, R is a C1-20 alkyl group, optionally branched by the alkyl group, the C1-20 alkyl group optionally being a cycloalkyl group or a cycloalkylalkyl group, and X and Y are independently a hydrogen, a C1-8 alkyl group, or a halogen.

8.

发明授权
Polymeric biomaterials derived from phenolic monomers and their medical uses 有权

公开(公告)号：US10774030B2

公开(公告)日：2020-09-15

申请号：US16065889

申请日：2016-06-03

申请人： Rutgers, The State University of New Jersey

发明人： Durgadas Bolikal , Joachim B. Kohn

IPC分类号： C07C69/732 , C08G64/10 , C07C69/734 , C07C233/51 , C07C69/84 , C08G64/38 , A61L31/18 , A61L31/14 , A61L31/16 , A61L31/06 , C08G64/06 , C08G64/12 , C07C69/40 , C07C233/47 , C07C69/736 , C07C69/36

摘要： Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues and hydroxybenzoic acid, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula. These biocompatible polymers or polymer compositions with enhanced bioresorbability and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.

9.

发明申请
PROSTACYCLIN COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开

公开(公告)号：US20200079724A1

公开(公告)日：2020-03-12

申请号：US16685751

申请日：2019-11-15

申请人： Insmed Incorporated

发明人： Vladimir MALININ , Walter PERKINS , Franziska LEIFER , Donna KONICEK , Zhili LI , Adam PLAUNT

IPC分类号： C07C69/734 , A61M16/14 , A61M15/00 , A61K47/34 , A61K47/28 , A61K47/24 , A61K47/14 , A61K9/51 , A61K9/14 , A61K9/10 , A61K9/00 , A61P11/00 , A61P9/12 , A61K47/06 , A61K31/225 , A61K31/216 , A61K31/165 , C07C235/20 , C07C235/22 , C07C69/753 , C07C69/736 , A61K47/54 , A61K47/60 , C07C69/712

摘要： Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.