发明授权
- 专利标题: Antibodies to growth factor HTTER36
- 专利标题(中): 生长因子抗体HTTER36
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申请号: US10117178申请日: 2002-04-08
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公开(公告)号: US06884594B2公开(公告)日: 2005-04-26
- 发明人: Daniel R. Soppet , Haodong Li
- 申请人: Daniel R. Soppet , Haodong Li
- 申请人地址: US MD Rockville
- 专利权人: Human Genome Sciences, Inc.
- 当前专利权人: Human Genome Sciences, Inc.
- 当前专利权人地址: US MD Rockville
- 代理机构: Human Genome Sciences, Inc.
- 主分类号: A61K48/00
- IPC分类号: A61K48/00 ; C07K14/495 ; C12N1/21 ; C12N15/18 ; C07K16/22 ; C12N5/12 ; G01N33/53
摘要:
The present invention discloses Growth Factor HTTER36 polypeptides and polynucleotides encoding such polypeptides. Also disclosed are antibodies and fragments thereof that specifically bind to such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating cellular growth and differentiation, bone formation and wound healing. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia and to prevent the formation of extracellular matrix molecules in the liver and lung. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the invention.
公开/授权文献
- US20020137143A1 Growth factor HTTER36 公开/授权日:2002-09-26
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