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    Antibodies to growth factor HTTER36
    2.
    发明授权
    Antibodies to growth factor HTTER36 失效
    生长因子抗体HTTER36

    公开(公告)号：US06884594B2

    公开(公告)日：2005-04-26

    申请号：US10117178

    申请日：2002-04-08

    申请人： Daniel R. Soppet ,  Haodong Li

    发明人： Daniel R. Soppet ,  Haodong Li

    IPC分类号： A61K48/00 ,  C07K14/495 ,  C12N1/21 ,  C12N15/18 ,  C07K16/22 ,  C12N5/12 ,  G01N33/53

    CPC分类号： C07K14/495 ,  A61K48/00 ,  C12N2799/026

    摘要： The present invention discloses Growth Factor HTTER36 polypeptides and polynucleotides encoding such polypeptides. Also disclosed are antibodies and fragments thereof that specifically bind to such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating cellular growth and differentiation, bone formation and wound healing. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia and to prevent the formation of extracellular matrix molecules in the liver and lung. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the invention.

    摘要翻译： 本发明公开了生长因子HTTER36多肽和编码这种多肽的多核苷酸。 还公开了与这些多肽特异性结合的抗体及其片段。 还提供了通过重组技术和包括刺激细胞生长和分化，骨形成和伤口愈合的多肽的治疗用途产生这种多肽的方法。 还公开了抗这种多肽的拮抗剂及其作为治疗性肿瘤的治疗剂的用途，并且防止在肝脏和肺中形成细胞外基质分子。 还公开了用于检测本发明多肽的改变水平的诊断测定法和编码本发明多肽的核酸序列中的突变。

    GROWTH FACTOR HTTER36
    3.
    发明申请
    GROWTH FACTOR HTTER36 审中-公开
    增长因素HTTER36

    公开(公告)号：US20120016107A1

    公开(公告)日：2012-01-19

    申请号：US13008653

    申请日：2011-01-18

    申请人： Daniel R. Soppet ,  Haodong Li

    发明人： Daniel R. Soppet ,  Haodong Li

    IPC分类号： C07K16/18

    CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K14/495

    摘要： The present invention discloses Growth Factor HTTER36 (GDF3) polypeptides and polynucleotides encoding such polypeptides. Also provided are antibodies that bind HTTER36, including chimeric, humanized, and single chain antibodies.

    摘要翻译： 本发明公开了生长因子HTTER36（GDF3）多肽和编码这种多肽的多核苷酸。 还提供了结合HTTER36的抗体，包括嵌合，人源化和单链抗体。

    Growth factor HTTER36
    4.
    发明授权
    Growth factor HTTER36 失效

    公开(公告)号：US6004780A

    公开(公告)日：1999-12-21

    申请号：US827336

    申请日：1997-03-26

    申请人： Daniel R. Soppet ,  Haodong Li

    发明人： Daniel R. Soppet ,  Haodong Li

    IPC分类号： A61K48/00 ,  C07K14/495 ,  C12N1/21 ,  C12N15/18 ,  C12N5/00 ,  C12N15/63

    CPC分类号： C07K14/495 ,  A61K48/00 ,  C12N2799/026

    摘要： The present invention discloses Growth Factor HTTER36 polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating cellular growth and differentiation, bone formation and wound healing. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia and to prevent the formation of extracellular matrix molecules in the liver and lung. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

    Growth factor HTTER36
    5.
    发明授权
    Growth factor HTTER36 失效
    生长因子HTTER36

    公开(公告)号：US06413933B1

    公开(公告)日：2002-07-02

    申请号：US09357905

    申请日：1999-07-21

    申请人： Daniel R. Soppet ,  Haodong Li

    发明人： Daniel R. Soppet ,  Haodong Li

    IPC分类号： A61K3818

    CPC分类号： C07K14/495 ,  A61K48/00 ,  C12N2799/026

    摘要： The present invention discloses Growth Factor HTTER36 polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating cellular growth and differentiation, bone formation and wound healing. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia and to prevent the formation of extracellular matrix molecules in the liver and lung. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

    摘要翻译： 本发明公开了生长因子HTTER36多肽和编码这种多肽的多核苷酸。 还提供了通过重组技术和包括刺激细胞生长和分化，骨形成和伤口愈合的多肽的治疗用途产生此类多肽的方法。 还公开了抗这种多肽的拮抗剂及其作为治疗性肿瘤的治疗剂的用途，并且防止在肝脏和肺中形成细胞外基质分子。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。

    Connective Tissue Growth Factor-2
    7.
    发明申请
    Connective Tissue Growth Factor-2 审中-公开
    结缔组织生长因子-2

    公开(公告)号：US20070154908A1

    公开(公告)日：2007-07-05

    申请号：US11563870

    申请日：2006-11-28

    申请人： Haodong Li ,  Mark Adams

    发明人： Haodong Li ,  Mark Adams

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/475

    CPC分类号： C07K14/475 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K2319/00

    摘要： The present invention relates to a human CTGF-2 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist/inhibitors against such polypeptide. Also provided are methods of using the polypeptide therapeutically for enhancing the repair of connective and support tissue, promoting the attachment, fixation and stabilization of tissue implants and enhancing wound healing. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

    摘要翻译： 本发明涉及人CTGF-2多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法和针对这种多肽的抗体和拮抗剂/抑制剂。 还提供了用于治疗性地增强连接和支持组织的修复，促进组织植入物的附着，固定和稳定以及增强伤口愈合的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

    Antibodies to human chemokine beta-9
    9.
    发明授权
    Antibodies to human chemokine beta-9 有权
    人趋化因子β-9的抗体

    公开(公告)号：US07097985B2

    公开(公告)日：2006-08-29

    申请号：US10329472

    申请日：2002-12-27

    申请人： Haodong Li ,  Mark D. Adams

    发明人： Haodong Li ,  Mark D. Adams

    IPC分类号： G01N33/53 ,  C07K16/24 ,  C12N5/12

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/523 ,  G01N33/564 ,  G01N33/57426 ,  G01N33/6863 ,  G01N2333/52

    摘要： Human Ckβ-9 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ckβ-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the Ckβ-9 coding sequence and over-expression of the Ckβ-9 protein.

    摘要翻译： 公开了人Ckbeta-9多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种Ckbeta-9多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了诊断测定法，其检测Ckbeta-9编码序列中突变的存在和Ckbeta-9蛋白的过表达。